RT Journal Article
SR Electronic
T1 Pregnancy outcomes among African–American patients with systemic lupus erythematosus compared with controls
JF Lupus Science & Medicine
JO Lupus Sci & Med
FD Lupus Foundation of America
SP e000020
DO 10.1136/lupus-2014-000020
VO 1
IS 1
A1 April Barnado
A1 Lee Wheless
A1 Anna K Meyer
A1 Gary S Gilkeson
A1 Diane L Kamen
YR 2014
UL http://lupus.bmj.com/content/1/1/e000020.abstract
AB Objective In a study of Gullah African–Americans, we compared pregnancy outcomes before and after systemic lupus erythematosus (SLE) diagnosis to controls to test whether there is a predisease state that negativelyaffects pregnancy outcomes. Design Cases and controls reporting at least one pregnancy were included. Controls were all Gullah African-American females. We collected demographic, socioeconomic and pregnancy data. We modelled pregnancy outcome associations with case status using multiple logistic regression to calculate ORs. Results After adjustment for age, years of education, medical coverage and pregnancy number, compared with controls, cases were more likely to have any adverse outcome (OR 2.35, 95% CI 1.78 to 3.10), including stillbirth (OR 4.55, 95% CI 1.53 to 13.50), spontaneous abortion (OR 2.05, 95% CI 1.40 to 3.00), preterm birth (OR 2.58, 95% CI 1.58 to 4.20), low birth weight (OR 2.64, 95% CI 1.61 to 4.34) and preeclampsia (OR 1.80, 95% CI 1.08 to 3.01). The odds of adverse pregnancy outcomes all increased after SLE diagnosis compared with before diagnosis, even after adjustment for age, years of education, pregnancy number and medical coverage. Conclusion From a large cohort of African–American women, our findings suggest there may be a predisease state that predisposes to adverse pregnancy outcomes.