RT Journal Article
SR Electronic
T1 416 Big data in systemic lupus erythematosus: phenotypic disease expression of 171,000 adult patients
JF Lupus Science & Medicine
JO Lupus Sci & Med
FD Lupus Foundation of America
SP A195
OP A195
DO 10.1136/lupus-2017-000215.416
VO 4
IS Suppl 1
A1 Novo, M Pérez de Lis
A1 Gandía, M
A1 Pérez-Álvarez, R
A1 Brito-Zerón, P
A1 Kostov, B
A1 Siso-Almirall, A
A1 Superville, D
A1 Shoenfeld, Y
A1 Ramos-Casals, M
A1 Khamashta, MA
YR 2017
UL http://lupus.bmj.com/content/4/Suppl_1/A195.2.abstract
AB Background and aims Studying the distribution of SLE across geographic regions using a big data-driven approach may facilitate understanding of the corresponding genetic and environmental underpinnings.Methods We explored the potential of the Google search engine to collect and merge cohorts (>100 patients) of patients with systemic lupus erythematosus (SLE) reported in the Pubmed library. We made a text-word search in Google between 8th and 15th May 2015 using SLE and ”100...100000000 patients” and “site:http://www.ncbi.nlm.nih.gov/pubmed”. We collected the available data about study design, country, ethnicities, age and gender, clinical features and immunological markers.Results We merged the data of 133 SLE cohorts including 1 71 000 patients; gender was detailed in 130 cohorts:88% women(female:male ratio, 8,4). mean age at onset (29.89±3.48), at diagnosis (32.33±2.99).The countries contributing the most cohorts were the USA (31), Japan (8) and Spain (5). The main clinical features included arthritis in 72%,haematological abnormalities in 62%,malar rash in 50%,photosensitivity in 48%, renal involvement in 38%, oral ulcers in 34%, serositis in 30% and neurological involvement in 14%. Haematological abnormalities included lymphopenia in 43%,leukopenia in 38%,thrombocytopenia in13% and hemolytic anaemia in 4%.Positive autoantibodies included ANA in 91%,dSDNA in 62%,anti-Ro/SSA in 35%,antiRNP in 25%,antiSm in 21% and anti-La/SSB in 15%.Conclusions This is the largest reported study in SLE including nearly 2 00 000 cases that provides a big data picture of the worldwide expression of the disease, with a female:male ratio of 8,4, a mean age at diagnosis of 32 years, and with joints, haematological, skin and kidneys being the most frequent organs involved.