RT Journal Article SR Electronic T1 445 Predictors of good long-term renal outcomes JF Lupus Science & Medicine JO Lupus Sci & Med FD Lupus Foundation of America SP A213 OP A214 DO 10.1136/lupus-2017-000215.445 VO 4 IS Suppl 1 A1 W Fung A1 J Su A1 Z Touma A1 D Gladman YR 2017 UL http://lupus.bmj.com/content/4/Suppl_1/A213.3.abstract AB Background and aims To determine: 1-the predictive ability of proteinuria, urinary sediment (uRBCs) and serum creatinine (Cr) at 1 year to predict good long-term outcomes, and 2- the best proteinuria cut-off at 1 year to predict good long-term outcomes.Methods Retrospective analysis on 1849 patients. Patients with lupus nephritis (LN) (24 hour proteinuria [24H-P]>0.5 g/d) with at least 7 years’ follow-up were identified and baseline was defined as the onset of LN. Good renal outcome was defined as Cr <100 mmol/L and renal transplant/dialysis-free at 7 years.ROC curves examined the predictive power of Cr, 24H-P, and uRBCs at 1 year post-LN diagnosis with respect to good renal outcome. AUC were analysed for: a) 24H-P at year 1, b) absolute change in 24H-P between year 1 and 7, and c) percent change in 24H-P between year 1 and 7. The proteinuria cutoff was identified by optimising sensitivity/specificity.Results 101 LN patients were analysed with baseline 24H-P of 2.36±2.31 g/d. 24H-P of 0.6 g/d at 1 year after LN diagnosis best predicted good long-term renal outcome, with sensitivity 62%/specificity 70% (Figure 1).AUC analysis confirmed that 24H-P at 1 year, but not absolute/percent change, is a predictor of good long-term renal outcomes (Figures 1 and 2). uRBCs did not provide any predictive benefit while Cr at 1 year predicted long-term renal outcome with an AUC of 0.82 (Figure 2).Abstract 445 Figure 1 ROC curve of proteinuria at 1 year, absolute change and percentage of change between year 1 and 7.Abstract 445 Figure 2 Conclusions Proteinuria of 0.6 g/d at 1 year and Cr at 1 year post-LN diagnosis best predicted good long-term renal outcome. uRBCs did not offer any prognostic benefit.