RT Journal Article
SR Electronic
T1 Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
JF Lupus Science & Medicine
FD Lupus Foundation of America
SP e000187
DO 10.1136/lupus-2016-000187
VO 4
IS 1
A1 Sasha Bernatsky
A1 Héctor A Velásquez García
A1 John J Spinelli
A1 Patrick Gaffney
A1 Karin E Smedby
A1 Rosalind Ramsey-Goldman
A1 Sophia S Wang
A1 Hans-Olov Adami
A1 Demetrius Albanes
A1 Emanuele Angelucci
A1 Stephen M Ansell
A1 Yan W Asmann
A1 Nikolaus Becker
A1 Yolanda Benavente
A1 Sonja I Berndt
A1 Kimberly A Bertrand
A1 Brenda M Birmann
A1 Heiner Boeing
A1 Paolo Boffetta
A1 Paige M Bracci
A1 Paul Brennan
A1 Angela R Brooks-Wilson
A1 James R Cerhan
A1 Stephen J Chanock
A1 Jacqueline Clavel
A1 Lucia Conde
A1 Karen H Cotenbader
A1 David G Cox
A1 Wendy Cozen
A1 Simon Crouch
A1 Anneclaire J De Roos
A1 Silvia de Sanjose
A1 Simonetta Di Lollo
A1 W Ryan Diver
A1 Ahmet Dogan
A1 Lenka Foretova
A1 Hervé Ghesquières
A1 Graham G Giles
A1 Bengt Glimelius
A1 Thomas M Habermann
A1 Corinne Haioun
A1 Patricia Hartge
A1 Henrik Hjalgrim
A1 Theodore R Holford
A1 Elizabeth A Holly
A1 Rebecca D Jackson
A1 Rudolph Kaaks
A1 Eleanor Kane
A1 Rachel S Kelly
A1 Robert J Klein
A1 Peter Kraft
A1 Anne Kricker
A1 Qing Lan
A1 Charles Lawrence
A1 Mark Liebow
A1 Tracy Lightfoot
A1 Brian K Link
A1 Marc Maynadie
A1 James McKay
A1 Mads Melbye
A1 Thierry J Molina
A1 Alain Monnereau
A1 Lindsay M Morton
A1 Alexandra Nieters
A1 Kari E North
A1 Anne J Novak
A1 Kenneth Offit
A1 Mark P Purdue
A1 Marco Rais
A1 Jacques Riby
A1 Eve Roman
A1 Nathaniel Rothman
A1 Gilles Salles
A1 Gianluca Severi
A1 Richard K Severson
A1 Christine F Skibola
A1 Susan L Slager
A1 Alex Smith
A1 Martyn T Smith
A1 Melissa C Southey
A1 Anthony Staines
A1 Lauren R Teras
A1 Carrie A Thompson
A1 Hervé Tilly
A1 Lesley F Tinker
A1 Anne Tjonneland
A1 Jenny Turner
A1 Claire M Vajdic
A1 Roel C H Vermeulen
A1 Joseph Vijai
A1 Paolo Vineis
A1 Jarmo Virtamo
A1 Zhaoming Wang
A1 Stephanie Weinstein
A1 Thomas E Witzig
A1 Andrew Zelenetz
A1 Anne Zeleniuch-Jacquotte
A1 Yawei Zhang
A1 Tongzhang Zheng
A1 Mariagrazia Zucca
A1 Ann E Clarke
YR 2017
UL http://lupus.bmj.com/content/4/1/e000187.abstract
AB Objective Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions These data suggest several plausible genetic links between DLBCL and SLE.