TY - JOUR T1 - Jaccoud’s arthropathy in SLE: findings from a Latin American multiethnic population JF - Lupus Science & Medicine JO - Lupus Sci Med Lupus Sci Med DO - 10.1136/lupus-2019-000343 VL - 6 IS - 1 SP - e000343 AU - Rosana Quintana AU - Guillermo Pons-Estel AU - Karen Roberts AU - Monica Sacnún AU - Guillermo Berbotto AU - Mercedes A Garcia AU - Veronica Saurit AU - Leonor Barile-Fabris AU - Eduardo M Acevedo-Vazquez AU - João C Tavares Brenol AU - Emilia I Sato AU - Antonio Iglesias AU - Oscar Uribe AU - Graciela Alarcon AU - Bernardo A Pons-Estel Y1 - 2019/08/01 UR - http://lupus.bmj.com/content/6/1/e000343.abstract N2 - Objective To compare the clinical, laboratory and outcome features of SLE patients with and without Jaccoud’s arthropathy (JA) from the Grupo Latino Americano De Estudio del Lupus (GLADEL) cohort.Methods 1480 patients with SLE [(34 centres, 9 Latin American countries with a recent diagnosis (≤2 years)] constitute the GLADEL cohort. JA was defined as reducible deformity of the metacarpophalangeal axis, without radiographic erosions at any time. Within this cohort, a nested case–control study was carried out. Control was matched for age, gender and centre in a 1:3 proportion. The variables included were: sociodemographic, clinical and immunological features, disease activity, damage and mortality. Comparisons were performed with Wilcoxon and χ2 tests for continuous and categorical variables, respectively. ORs and 95% CIs and Kaplan-Meier survival curve were estimated.Results Of 1480 patients, 17 (1.1%) JA patients were identified; 16 (94.1%) of them were women, mean age: 31.0 years (SD 12.0). Five (29.4%) patients presented JA at SLE diagnosis and 12 (70.6%) after. The median follow-up time and all disease features were comparable in both groups except for a higher frequency of pneumonitis in the patients with JA [4 (23.5) vs 1 (2.0); p=0.012; (OR: 15.4; 95% CI 1.6 to 149.6)]. The SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage Index and the Kaplan-Meier survival curve were similar in both groups.Conclusion JA may tend to appear early in the course of SLE; it seems not to have an impact on disease activity, damage accrual or in survival. ER -