RT Journal Article
SR Electronic
T1 Serum uric acid is associated with damage in patients with systemic lupus erythematosus
JF Lupus Science & Medicine
JO Lupus Sci Med
FD Lupus Foundation of America
SP e000366
DO 10.1136/lupus-2019-000366
VO 7
IS 1
A1 Claudia Elera-Fitzcarrald
A1 Cristina Reátegui-Sokolova
A1 Rocio Violeta Gamboa-Cardenas
A1 Mariela Medina
A1 Francisco Zevallos
A1 Victor Román Pimentel-Quiroz
A1 Jorge Mariano Cucho-Venegas
A1 José Alfaro-Lozano
A1 Zoila Rodriguez-Bellido
A1 Cesar Augusto Pastor-Asurza
A1 Risto Alfredo Perich-Campos
A1 Graciela S Alarcón
A1 Manuel Francisco Ugarte-Gil
YR 2020
UL http://lupus.bmj.com/content/7/1/e000366.abstract
AB Introduction Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.Objective To determine whether serum uric acid levels are associated with new damage in patients with SLE.Methods This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.Results We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).Conclusion Higher serum uric acid levels are associated with global damage in patients with SLE.