PT - JOURNAL ARTICLE AU - Menor-Almagro, Raúl AU - Muñoz, Alejandro AU - Rúa-Figueroa, Iñigo AU - Martín-Martínez, María Auxiliadora AU - Olivé, Alejandro AU - Galindo, María AU - Calvo-Alén, Jaime AU - Fernández-Nebro, Antonio AU - López-Longo, Javier AU - Andrés, Mariano AU - Tomero, Eva AU - Uriarte, Esther AU - Freire, Mercedes AU - Narváez, Javier AU - Pego-Reigosa, José María AU - , TI - P149 Association between geographic and climatological conditions and cutaneous manifestations in lupus patients from the Spanish rheumatology society lupus registry cohort AID - 10.1136/lupus-2020-eurolupus.192 DP - 2020 Mar 01 TA - Lupus Science & Medicine PG - A102--A103 VI - 7 IP - Suppl 1 4099 - http://lupus.bmj.com/content/7/Suppl_1/A102.2.short 4100 - http://lupus.bmj.com/content/7/Suppl_1/A102.2.full SO - Lupus Sci Med2020 Mar 01; 7 AB - Background/Purpose Ultraviolet radiations act by modifying DNA in sun-exposed skin of lupus patients. We develop a study to analyze the association between climatological conditions and cutaneous manifestations in systemic lupus erythematosus (SLE).Methods Patients data from Spanish Rheumatology Society Lupus Registry (RELESSER) cohort were retrospectively analyzed for presence of cutaneous lesions (alopecia, photosensitivity, malar rash, discoid lesions, oral ulcers and subacute lesions). We included patients who were assessed in rheumatology services from January 2011 to December 2012. Data of climatological conditions throughout the Spanish geography were provided by the Spanish Meteorological Agency.Results A total of 2919 patients were included, 87.3% female. Others biological and clinical data are showed in table 1. In the multivariable model, positive associations were observed between coastal regions OR 1.470 (95% CI:1.080–2.001 p=0,014), anti-DNA OR 1.806 (95% CI:1.276–2.556, p=0.001), antiphospholipids antibodies OR 1.428 (95% CI:1.093–1.864 p=0.009), serositis OR 1.557 (95% CI:1.181–2.053 p=0.002) and arthritis OR 1.804 (95% CI:1.258–2.587 p=0,001). Negative associations were observed between females OR 0.412 (95% CI:0.284–0.599, p=0.000) and antimalarial drugs OR 0.469 (95% CI:0.327–0.671, p=0.000).View this table:Abstract P149 Table 1 Geographical, climatological, biologic and clinical patients characteristicsConclusion Although the influence of global and ultraviolet radiations on the development of cutaneous lesions in SLE have been suggested, the results of our study does not support an association between the diverse climatological conditions and cutaneous manifestations in SLE. However we observed an independent association with living in coastal areas.