TY - JOUR T1 - Outcomes of pregnancy and associated factors in sub-Saharan African women with systemic lupus erythematosus: a scoping review JF - Lupus Science & Medicine JO - Lupus Sci Med DO - 10.1136/lupus-2020-000400 VL - 7 IS - 1 SP - e000400 AU - Mickael Essouma AU - Jan René Nkeck AU - Kodoume Motolouze AU - Jean Joel Bigna AU - Paul Tchaptchet AU - Grâce Anita Nkoro AU - Stéphane Ralandison AU - Eric Hachulla Y1 - 2020/06/01 UR - http://lupus.bmj.com/content/7/1/e000400.abstract N2 - Objective To scope and summarise available literature on the outcomes of pregnancy and associated factors in sub-Saharan African women with SLE.Methods Electronic databases and reference lists of retrieved articles were searched to identify relevant studies published from 1 January 2000 to 28 October 2019. Data were combined through narrative synthesis.Results We included four studies retrospectively reporting a total of 137 pregnancies in 102 women over a 26-year period. Mean age at conception ranged from 27.2 to 39.9 years. Kidney damage, the predominant organ manifestation before conception, was reported in 43 (42.2%) patients. Ninety-seven (70.8%) pregnancies resulted in 98 live births. SLE flares occurred in 44 (32.2%) pregnancies, mainly skin (20.4%) and renal (18.2%) flares. Major adverse pregnancy outcomes (APOs) were preterm birth 38.8%, low birth weight 29.8%, pregnancy loss 29.2% and pre-eclampsia 24.8%. The main factors associated with APOs were nephritis and SLE flares.Conclusion Over two-thirds of pregnancies resulted in live birth in this cohort of sub-Saharan African women with SLE. The main APOs and associated factors described in other parts of the world are also seen in this region, but with high rates of APOs. A large prospective multinational study is warranted for more compelling evidence. ER -