RT Journal Article SR Electronic T1 Evaluation of SLE arthritis using frequency domain optical imaging JF Lupus Science & Medicine JO Lupus Sci Med FD Lupus Foundation of America SP e000495 DO 10.1136/lupus-2021-000495 VO 8 IS 1 A1 Marone, Alessandro A1 Tang, Wei A1 Kim, Youngwan A1 Chen, Tommy A1 Danias, George A1 Guo, Cathy A1 Gartshteyn, Yevgeniya A1 Khalili, Leila A1 Kim, Hyun A1 Hielscher, Andreas A1 Askanase, Anca D YR 2021 UL http://lupus.bmj.com/content/8/1/e000495.abstract AB Objectives Systemic lupus erythematosus (SLE) affects the joints in up to 95% of patients. The diagnosis and evaluation of SLE arthritis remain challenging in both practice and clinical trials. Frequency domain optical imaging (FDOI) has been previously used to assess joint involvement in inflammatory arthritis. The objective of this study was to evaluate FDOI in SLE arthritis.Methods Ninety-six proximal interphalangeal (PIP) joints from 16 patients with SLE arthritis and 60 PIP joints from 10 age-matched, gender-matched and race/ethnicity-matched controls were examined. A laser beam with a wavelength of 670 nm, 1 mm in diameter and intensity modulated at 300 MHz and 600 MHz was directed onto the dorsal surface of each joint, scanning across a sagittal plane. The transmitted light intensities and phase shifts were measured with an intensified charge-coupled device camera. The data were analysed using Discriminant Analysis and Support Vector Machine algorithms.Results The amplitude and phase of the transmitted light were significantly different between SLE and control PIPs (p<0.05). Receiver operating characteristic (ROC) analysis of cross-validated models showed an Area Under the ROC Curve (AUC)of 0.89 with corresponding sensitivity of 95%, specificity of 79%, and accuracy of 80%.Conclusion This study is the first evaluation of optical methods in the assessment of SLE arthritis; there was a statistically significant difference in the FDOI signals between patients with SLE and healthy volunteers. The results show that FDOI may have the potential to provide an objective, user-independent, evaluation of SLE PIP joints arthritis.Data are available upon reasonable request. Data is available upon reasonable request. Requests may be made to Anca Askanase, MD at ada20@cumc.columbia.edu.