PT  - JOURNAL ARTICLE
AU  - Porpon Rotjanapan
AU  - Aunyakant Jaroensukrungruang
AU  - Prapaporn Pisitkun
AU  - Pintip Ngamjanyaporn
AU  - Jittima Manonai
AU  - Vorthon Sawaswong
AU  - Prangwalai Chanchaem
AU  - Sunchai Payungporn
TI  - Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand
AID  - 10.1136/lupus-2021-000551
DP  - 2021 Oct 01
TA  - Lupus Science & Medicine
PG  - e000551
VI  - 8
IP  - 1
4099  - http://lupus.bmj.com/content/8/1/e000551.short
4100  - http://lupus.bmj.com/content/8/1/e000551.full
SO  - Lupus Sci Med2021 Oct 01; 8
AB  - Objective The risk factors associated with urinary tract infections (UTIs) in patients with SLE remain uncertain. We evaluated the vaginal microbiota pattern and its potential UTI-associated risk factors.Methods A pilot cross-sectional study of patients with SLE was conducted at Ramathibodi Hospital, Bangkok, Thailand, during 2019–2020. Patients’ demographic data and relevant information were collected. Vaginal microbiota was assessed in all patients and in 10 healthy volunteers.Results Fifty-two patients were enrolled (mean age: 46.1 years). All patients had SLE that was in low disease activity. As per the Simpson_e index, the within-group alpha diversity of the vaginal microbiota was low in the SLE with UTI and SLE receiving trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis groups. Multivariate logistic regression analysis revealed that TMP-SMX prophylaxis (adjusted OR (AOR), 30.96; 95% CI 3.63 to 264.11; p=0.002), elevated C3 levels (AOR, 35.33; 95% CI 1.33 to 936.67; p=0.033) and presence of Veillonella dispar in the vaginal microbiota (AOR, 6.68; 95% CI 1.27 to 35.07; p=0.025) were associated with UTI.Conclusions The vaginal microbiota diversity differed between patients with lupus with and without UTI, and unnecessary administration of TMP-SMX prophylaxis may affect the alpha diversity of the vaginal microbiota.Data are available in a public, open access repository.