RT Journal Article SR Electronic T1 1401 Effects of anifrolumab on renal disease in patients with systemic lupus erythematosus JF Lupus Science & Medicine JO Lupus Sci Med FD Lupus Foundation of America SP A58 OP A58 DO 10.1136/lupus-2021-lupus21century.78 VO 8 IS Suppl 2 A1 Morand, Eric F A1 Furie, Richard A A1 Tanaka, Yoshiya A1 Takeuchi, Tsutomu A1 Abreu, Gabriel A1 Tummala, Raj A1 Lindholm, Catharina YR 2021 UL http://lupus.bmj.com/content/8/Suppl_2/A58.1.abstract AB Background The type I interferon (IFN) receptor antibody, anifrolumab, has shown efficacy in patients with systemic lupus erythematosus (SLE) in the phase 3 TULIP-1 and TULIP-2 trials. Type I IFN dysregulation is associated with lupus nephritis (LN) pathogenesis. Pooled TULIP data were analyzed to assess baseline characteristics of patients with and without renal involvement and to evaluate the effects of anifrolumab on renal disease.Methods TULIP-1 and TULIP-2 were randomized, placebo-controlled trials of intravenous anifrolumab in patients with moderate to severe SLE despite standard therapy, which excluded patients with severe active LN. Renal involvement at baseline was defined as any of the following: British Isles Lupus Assessment Group(BILAG)-2004 renal score A–C; SLE Disease Activity Index 2000 (SLEDAI-2K) renal score >0; urine protein–creatinine ratio (UPCR) >0.5 mg/mg. Baseline characteristics were evaluated in patients with and without renal involvement, and the following endpoints were compared for the anifrolumab 300 mg and placebo groups: cumulative UPCR (area under the curve, AUC) through Week (W)52; percentage of patients with UPCR >0.5 mg/mg at baseline who improved to UPCR ≤0.5 mg/mg at W52; cumulative glucocorticoid (GC) use (AUC) through W52; and percentage changes in complement C3/C4 from baseline to W52.Results Of the 726 patients in TULIP-1/-2 (anifrolumab, n=360; placebo, n=366), 99 had renal involvement at baseline (anifrolumab, n=45; placebo, n=54), 57 of whom had UPCR >0.5 mg/mg (anifrolumab, n=24; placebo, n=33). Patients with vs without renal involvement had a lower mean age (37.8 vs 42.4 years) and were more likely to be male (14.1% vs 6.1%), Asian (16.2% vs 9.6%), IFN gene signature high (89.9% vs 81.5%), and anti-dsDNA positive (69.7% vs 40.4%); have a SLEDAI-2K score ≥10 (91.9% vs 68.4%); and be receiving GC ≥10 mg/day (67.7% vs 49.1%) or mycophenolate (26.3% vs 11.5%) at baseline. Among patients with baseline renal involvement, anifrolumab treatment was associated with a greater improvement vs placebo in cumulative UPCR (AUC) through W52 (table 1). More patients improved from UPCR >0.5 mg/mg at baseline to ≤0.5 mg/mg at W52 with anifrolumab vs placebo (table 1). Among patients with renal involvement, cumulative GC use (AUC) through W52 was lower with anifrolumab vs placebo and there were greater improvements in C3/C4 from baseline to W52 (table 1).View this table:Abstract 1401 Table 1 Renal endpoints in TULIP-1 and TULIP-2Conclusions TULIP data suggest renal benefit with anifrolumab in patients with SLE with mild/stable renal disease, supporting further investigation into anifrolumab’s efficacy in patients with active LN.Acknowledgments Writing assistance by Rosie Butler, PhD, of JK Associates Inc., part of Fishawack Health. This study was sponsored by AstraZeneca.Trial Registration NCT02446912 and NCT02446899