PT - JOURNAL ARTICLE AU - van Vollenhoven, Ronald F AU - Bertsias, George AU - Doria, Andrea AU - Isenberg, David AU - Morand, Eric AU - Petri, Michelle A AU - Pons-Estel, Bernardo A AU - Rahman, Anisur AU - Ugarte-Gil, Manuel Francisco AU - Voskuyl, Alexandre AU - Arnaud, Laurent AU - Bruce, Ian N AU - Cervera, Ricard AU - Costedoat-Chalumeau, Nathalie AU - Gordon, Caroline AU - Houssiau, Frédéric A AU - Mosca, Marta AU - Schneider, Matthias AU - Ward, Michael M AU - Alarcon, Graciela AU - Aringer, Martin AU - Askanase, Anca D AU - Bae, Sang-Cheol AU - Bootsma, Hendrika AU - Boumpas, Dimitrios T AU - Brunner, Hermine AU - Clarke, Ann Elaine AU - Coney, Cindy AU - Czirják, László AU - Dörner, Thomas AU - Faria, Raquel AU - Fischer, Rebecca AU - Fritsch-Stork, Ruth AU - Inanc, Murat AU - Jacobsen, Søren AU - Jayne, David AU - Kuhn, Annegret AU - van Leeuw, Bernadette AU - Limper, Maarten AU - Mariette, Xavier AU - Navarra, Sandra AU - Nikpour, Mandana AU - Olesinska, Marzena Helena AU - Pons-Estel, Guillermo AU - Romero-Diaz, Juanita AU - Rubio, Blanca AU - Schoenfeld, Yehuda AU - Bonfá, Eloisa AU - Smolen, Josef AU - Teng, Y K Onno AU - Tincani, Angela AU - Tsang-A-Sjoe, Michel AU - Vasconcelos, Carlos AU - Voss, Anne AU - Werth, Victoria P AU - Zakharhova, Elena AU - Aranow, Cynthia TI - 2021 DORIS definition of remission in SLE: final recommendations from an international task force AID - 10.1136/lupus-2021-000538 DP - 2021 Nov 01 TA - Lupus Science & Medicine PG - e000538 VI - 8 IP - 1 4099 - http://lupus.bmj.com/content/8/1/e000538.short 4100 - http://lupus.bmj.com/content/8/1/e000538.full SO - Lupus Sci Med2021 Nov 01; 8 AB - Objective To achieve consensus on a definition of remission in SLE (DORIS).Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.Data are available upon reasonable request.