RT Journal Article
SR Electronic
T1 2021 DORIS definition of remission in SLE: final recommendations from an international task force
JF Lupus Science & Medicine
JO Lupus Sci Med
FD Lupus Foundation of America
SP e000538
DO 10.1136/lupus-2021-000538
VO 8
IS 1
A1 Ronald F van Vollenhoven
A1 George Bertsias
A1 Andrea Doria
A1 David Isenberg
A1 Eric Morand
A1 Michelle A Petri
A1 Bernardo A Pons-Estel
A1 Anisur Rahman
A1 Manuel Francisco Ugarte-Gil
A1 Alexandre Voskuyl
A1 Laurent Arnaud
A1 Ian N Bruce
A1 Ricard Cervera
A1 Nathalie Costedoat-Chalumeau
A1 Caroline Gordon
A1 Frédéric A Houssiau
A1 Marta Mosca
A1 Matthias Schneider
A1 Michael M Ward
A1 Graciela Alarcon
A1 Martin Aringer
A1 Anca D Askanase
A1 Sang-Cheol Bae
A1 Hendrika Bootsma
A1 Dimitrios T Boumpas
A1 Hermine Brunner
A1 Ann Elaine Clarke
A1 Cindy Coney
A1 László Czirják
A1 Thomas Dörner
A1 Raquel Faria
A1 Rebecca Fischer
A1 Ruth Fritsch-Stork
A1 Murat Inanc
A1 Søren Jacobsen
A1 David Jayne
A1 Annegret Kuhn
A1 Bernadette van Leeuw
A1 Maarten Limper
A1 Xavier Mariette
A1 Sandra Navarra
A1 Mandana Nikpour
A1 Marzena Helena Olesinska
A1 Guillermo Pons-Estel
A1 Juanita Romero-Diaz
A1 Blanca Rubio
A1 Yehuda Schoenfeld
A1 Eloisa Bonfá
A1 Josef Smolen
A1 Y K Onno Teng
A1 Angela Tincani
A1 Michel Tsang-A-Sjoe
A1 Carlos Vasconcelos
A1 Anne Voss
A1 Victoria P Werth
A1 Elena Zakharhova
A1 Cynthia Aranow
YR 2021
UL http://lupus.bmj.com/content/8/1/e000538.abstract
AB Objective To achieve consensus on a definition of remission in SLE (DORIS).Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.Data are available upon reasonable request.