RT Journal Article
SR Electronic
T1 2021 DORIS definition of remission in SLE: final recommendations from an international task force
JF Lupus Science & Medicine
JO Lupus Sci Med
FD Lupus Foundation of America
SP e000538
DO 10.1136/lupus-2021-000538
VO 8
IS 1
A1 van Vollenhoven, Ronald F
A1 Bertsias, George
A1 Doria, Andrea
A1 Isenberg, David
A1 Morand, Eric
A1 Petri, Michelle A
A1 Pons-Estel, Bernardo A
A1 Rahman, Anisur
A1 Ugarte-Gil, Manuel Francisco
A1 Voskuyl, Alexandre
A1 Arnaud, Laurent
A1 Bruce, Ian N
A1 Cervera, Ricard
A1 Costedoat-Chalumeau, Nathalie
A1 Gordon, Caroline
A1 Houssiau, Frédéric A
A1 Mosca, Marta
A1 Schneider, Matthias
A1 Ward, Michael M
A1 Alarcon, Graciela
A1 Aringer, Martin
A1 Askanase, Anca D
A1 Bae, Sang-Cheol
A1 Bootsma, Hendrika
A1 Boumpas, Dimitrios T
A1 Brunner, Hermine
A1 Clarke, Ann Elaine
A1 Coney, Cindy
A1 Czirják, László
A1 Dörner, Thomas
A1 Faria, Raquel
A1 Fischer, Rebecca
A1 Fritsch-Stork, Ruth
A1 Inanc, Murat
A1 Jacobsen, Søren
A1 Jayne, David
A1 Kuhn, Annegret
A1 van Leeuw, Bernadette
A1 Limper, Maarten
A1 Mariette, Xavier
A1 Navarra, Sandra
A1 Nikpour, Mandana
A1 Olesinska, Marzena Helena
A1 Pons-Estel, Guillermo
A1 Romero-Diaz, Juanita
A1 Rubio, Blanca
A1 Schoenfeld, Yehuda
A1 Bonfá, Eloisa
A1 Smolen, Josef
A1 Teng, Y K Onno
A1 Tincani, Angela
A1 Tsang-A-Sjoe, Michel
A1 Vasconcelos, Carlos
A1 Voss, Anne
A1 Werth, Victoria P
A1 Zakharhova, Elena
A1 Aranow, Cynthia
YR 2021
UL http://lupus.bmj.com/content/8/1/e000538.abstract
AB Objective To achieve consensus on a definition of remission in SLE (DORIS).Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.Data are available upon reasonable request.