TY - JOUR T1 - Risk factors for changes in carotid intima media thickness and plaque over 5 years in women with systemic lupus erythematosus JF - Lupus Science & Medicine JO - Lupus Sci Med DO - 10.1136/lupus-2021-000548 VL - 8 IS - 1 SP - e000548 AU - Apinya Lertratanakul AU - Julia Sun AU - Peggy W Wu AU - Jungwha Lee AU - Alan Dyer AU - William Pearce AU - David McPherson AU - Kim Sutton-Tyrrell AU - Trina Thompson AU - Emma Barinas-Mitchell AU - Rosalind Ramsey-Goldman Y1 - 2021/12/01 UR - http://lupus.bmj.com/content/8/1/e000548.abstract N2 - Objective To investigate the occurrence of and risk factors for progression of carotid intima media thickness (IMT) and plaque in women with and without SLE.Methods A cohort of 149 women with SLE and 126 controls participated in SOLVABLE (Study of Lupus Vascular and Bone Long-term Endpoints). Demographics, cardiovascular and SLE factors, and laboratory assessments were collected at baseline. Carotid IMT and plaque were measured using B-mode ultrasound at baseline and at 5-year follow-up. Regression models were used to identify predictors of progression in carotid IMT and plaque; multivariate models were adjusted for age, hypertension and total cholesterol to high-density lipoprotein ratio.Results The mean±SD follow-up time was 5.35±0.60 years in cases and 5.62±0.66 years in controls. The mean IMT change per year was 0.008±0.015 mm in cases and 0.005±0.019 mm in controls (p=0.24). At follow-up, 31.5% of cases and 15% of controls had plaque progression, with a relative risk for plaque progression of 2.09 (95% CI 1.30 to 3.37). In SLE cases, higher fasting glucose and lower fibrinogen were associated with IMT progression after adjustment. Larger waist circumference and non-use of hydroxychloroquine were associated with plaque progression after adjustment.Conclusion Potential modifiable risk factors for carotid IMT and plaque progression in women with SLE were identified, suggesting that monitoring of glucose and waist circumference and use of hydroxychloroquine may be beneficial.Data are available upon reasonable request. Additional supplemental data are available upon request. ER -