PT  - JOURNAL ARTICLE
AU  - Kwan, Andrew
AU  - Rayes, Hanan Al
AU  - Lazova, Tijana
AU  - Anderson, Nicole
AU  - Bonilla, Dennisse
AU  - Su, Jiandong
AU  - Touma, Zahi
TI  - Herpes zoster in SLE: prevalence, incidence and risk factors
AID  - 10.1136/lupus-2021-000574
DP  - 2022 Jan 01
TA  - Lupus Science & Medicine
PG  - e000574
VI  - 9
IP  - 1
4099  - http://lupus.bmj.com/content/9/1/e000574.short
4100  - http://lupus.bmj.com/content/9/1/e000574.full
SO  - Lupus Sci Med2022 Jan 01; 9
AB  - Objectives This study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.Methods 491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.Results Prevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.Conclusions HZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.All data relevant to the study are included in the article or uploaded as supplementary information. Not applicable.