RT Journal Article
SR Electronic
T1 Herpes zoster in SLE: prevalence, incidence and risk factors
JF Lupus Science & Medicine
JO Lupus Sci Med
FD Lupus Foundation of America
SP e000574
DO 10.1136/lupus-2021-000574
VO 9
IS 1
A1 Andrew Kwan
A1 Hanan Al Rayes
A1 Tijana Lazova
A1 Nicole Anderson
A1 Dennisse Bonilla
A1 Jiandong Su
A1 Zahi Touma
YR 2022
UL http://lupus.bmj.com/content/9/1/e000574.abstract
AB Objectives This study aimed to evaluate the prevalence and incidence of herpes zoster (HZ) events and describe its associated factors in a study of patients with SLE.Methods 491 consecutive SLE participants were screened for HZ events using a patient-reported questionnaire to capture outcomes on pain and other characteristics associated with HZ events. Sociodemographic, clinical and laboratory measures were also analysed, and time-dependent Cox regression survival analyses were performed to investigate factors associated with HZ events.Results Prevalence of HZ was 30.5%, incidence was 14.3 cases per 1000 person-years. Lymphopenia and glucocorticoid dosing were significantly associated with HZ events.Conclusions HZ is highly prevalent in SLE, which may be linked to disease-related and treatment-related effects on cellular immunity. Our results suggest that the presence of certain risk factors may be useful to allow identification of patients at risk of HZ and improve its management in patients with SLE.All data relevant to the study are included in the article or uploaded as supplementary information. Not applicable.