PT - JOURNAL ARTICLE AU - Manuel Francisco Ugarte-Gil AU - Rocio Violeta Gamboa-Cardenas AU - Cristina Reátegui-Sokolova AU - Victor Román Pimentel-Quiroz AU - Mariela Medina AU - Claudia Elera-Fitzcarrald AU - Francisco Zevallos AU - Cesar Augusto Pastor-Asurza AU - Jeniffer Lofland AU - Federico Zazzetti AU - Chetan S Karyekar AU - Graciela S Alarcón AU - Risto Alfredo Perich-Campos TI - LLDAS (lupus low disease activity state) and/or remission are associated with less damage accrual in patients with systemic lupus erythematosus from a primarily Mestizo population: data from the Almenara Lupus Cohort AID - 10.1136/lupus-2021-000616 DP - 2022 Feb 01 TA - Lupus Science & Medicine PG - e000616 VI - 9 IP - 1 4099 - http://lupus.bmj.com/content/9/1/e000616.short 4100 - http://lupus.bmj.com/content/9/1/e000616.full SO - Lupus Sci Med2022 Feb 01; 9 AB - Objective To determine if achieving lupus low disease activity state (LLDAS) or remission prevents damage accrual in a primarily Mestizo population.Methods Patients with SLE from a single-centre cohort with at least two visits occurring every 6 months were included. The definitions used were the following: for remission, the 2021 Definition Of Remission In SLE; and for LLDAS, the Asia Pacific Lupus Collaboration. Damage accrual was ascertained with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Univariable and three multivariable interval-censored survival regression models were done: (1) remission versus not on remission; (2) LLDAS/remission versus active; and (3) remission and LLDAS (not on remission) versus active. Three similar multivariable models were also examined considering the duration on each state. Possible confounders included in these analyses were gender, age at diagnosis, socioeconomic status, educational level, disease duration, antimalarial use and SDI at baseline.Results Two hundred and eighty-one patients were included. Eighty-three patients (29.5%) showed increased SDI during the follow-up. In the analyses of remission, being on remission predicted a lower probability of damage (HR=0.456; 95% CI 0.256 to 0.826; p=0.010). In the analyses of LLDAS/remission, being on LLDAS/remission predicted a lower damage (HR=0.503; 95% CI 0.260 to 0.975; p=0.042). When both states were considered, remission but not LLDAS (not on remission) predicted a lower probability of damage (HR=0.423; 95% CI 0.212 to 0.846; p=0.015 and HR=0.878; 95% CI 0.369 to 2.087; p=0.768, respectively). When the duration of these states was taken into account, remission, LLDAS/remission and LLDAS not on remission were associated with a lower probability of damage accrual.Conclusions LLDAS and/or remission were associated with a lower probability of damage accrual.