PT  - JOURNAL ARTICLE
AU  - Guajardo-Jauregui, N
AU  - Colunga-Pedraza, IJ
AU  - Galarza-Delgado, DA
AU  - Azpiri-Lopez, JR
AU  - Cardenas-De La Garza, JA
AU  - Lugo-Perez, S
TI  - PO.3.58 Association of anti-double stranded dna antibody titers and echocardiographic parameters in systemic lupus erythematosus patients
AID  - 10.1136/lupus-2022-elm2022.88
DP  - 2022 Oct 01
TA  - Lupus Science & Medicine
PG  - A56--A57
VI  - 9
IP  - Suppl 2
4099  - http://lupus.bmj.com/content/9/Suppl_2/A56.short
4100  - http://lupus.bmj.com/content/9/Suppl_2/A56.full
SO  - Lupus Sci Med2022 Oct 01; 9
AB  - Purpose Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, characterized by the deposition of immunocomplexes in vital organs such as the heart, brain, and kidneys. High autoantibodies titers have been associated with a worse cardiovascular prognosis. Anti-double stranded DNA (anti-dsDNA) antibody has been associated with skin, brain and kidney injury, however, information about its association with cardiovascular risk is scarce. We aimed to evaluate the association between measure anti-dsDNA antibody titers and echocardiographic parameters in SLE patients.Methods This was a cross-sectional study. We recruited a total of 67 patients with SLE diagnosis, according to the 2019 EULAR/ACR classification criteria, aged ≥18 years. A transthoracic echocardiogram was performed by two certified echocardiographers blinded to clinical information. A blood sample was drawn to measure anti-dsDNA titers. Distribution was evaluated with the Kolmogorov-Smirnov test. Correlations between anti-dsDNA antibody titers and echocardiographic parameters were determined with Spearman’s correlation coefficient (rs). A p-value < 0.05 was considered statistically significant.Results Median age of SLE patients was 37 (24–42) years, 89.6% were women, and 20.9% had hypertension diagnosis. Demographic and clinical characteristics are shown in Table 1. We found a moderate positive correlation between anti-dsDNA antibody titers and left ventricular mass index (rs = 0.332, p = 0.006), a moderate positive correlation between anti-dsDNA antibody titers and the ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) (rs = 0.368, p = 0.003), and a moderate positive correlation between anti-dsDNA and pulmonary arterial systolic pressure (PASP) (rs = 0.326, p = 0.013) (Table 2).View this table:Abstract PO.3.58 Table 1 Demographic and clinical characteristicsView this table:Abstract PO.3.58 Table 2 Correlation between anti-dsDNA antibodies and echocardiographic parametersConclusions Higher titers of anti-dsDNA antibody are associated with higher left ventricular mass index, E/e’, and PSAP, which could lead to the development of ventricular hypertrophy, diastolic dysfunction, and pulmonary hypertension respectively. The performance of a transthoracic echocardiogram may be helpful to detect early cardiovascular abnormalities in SLE patients, especially those with high anti-dsDNA antibody titers.