RT Journal Article SR Electronic T1 Impact of severe infections in SLE: an observational study from the Spanish national registry JF Lupus Science & Medicine JO Lupus Sci Med FD Lupus Foundation of America SP e000711 DO 10.1136/lupus-2022-000711 VO 9 IS 1 A1 Victor Moreno-Torres A1 María Martínez-Urbistondo A1 Angela Gutiérrez-Rojas A1 Raquel Castejón A1 Enrique Sánchez A1 Jorge Calderón-Parra A1 Pedro Durán-del Campo A1 Pablo Tutor A1 Susana Mellor-Pita A1 José Vázquez-Comendador A1 Juan A Vargas-Núñez A1 Guillermo Ruiz-Irastorza YR 2022 UL http://lupus.bmj.com/content/9/1/e000711.abstract AB Objective Infections are a common complication of SLE. Our objective was to evaluate their causes and impact on the survival of patients with SLE.Methods Analysis of the admissions and death causes in patients diagnosed with SLE from the Spanish Hospital Discharge Database and the infection-related deaths of the Spanish population from the National Statistical Institute, between 2016 and 2018.Only infections recorded as the main diagnosis were analysed (severe or clinically relevant infection).Results Among 18 430 admissions in patients with SLE, disease activity was the cause of admission in 19% of all patients and infection in 15%. However, infection was the main cause of death (25%) while SLE activity was responsible for only 6% of deaths (p<0.001). Severe infection exceeded SLE as a cause of death for patients dying at ages between 40–59 (23% vs 4%, p<0.001), 60–79 (26% vs 6%, p<0.001) and older than 80 years (25% vs 6%, p<0.001). Infection was the cause of death in 8% of the Spanish population, a significantly lower rate when compared with patients with SLE (p<0.001). Compared with the general population, infections were the highest relative cause of death in patients with SLE, particularly at younger ages: 40% vs 3% for those below 20 years old (p<0.01), 33% vs 4% between 20 and 39 (p<0.001), 23% vs 5% between 40 and 59 (p<0.001), 26% vs 5% between 60 and 79 (p<0.001) and 25% vs 9% for those older than 80 years (p<0.001).Conclusion Our nationwide study confirms that infections are the leading cause of death in SLE in Spain, with the highest proportion occurring in young patients with lupus compared with the general population of the same age range.Data are available on reasonable request. NA.