PT  - JOURNAL ARTICLE
AU  - Hui Jin
AU  - Shihang Zhou
AU  - Yangyiyi Yu
AU  - Ming Zhao
AU  - Haijing Wu
AU  - Hai Long
AU  - Siqi Fu
AU  - Ruifang Wu
AU  - Heng Yin
AU  - Jieyue Liao
AU  - Shuangyan Luo
AU  - Yu Liu
AU  - Qing Zhang
AU  - Peng Zhang
AU  - Yixin Tan
AU  - Shuaihantian Luo
AU  - Xin Huang
AU  - Fen Li
AU  - Guanghui Ling
AU  - Qianjin Lu
TI  - Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China
AID  - 10.1136/lupus-2022-000819
DP  - 2023 Mar 01
TA  - Lupus Science & Medicine
PG  - e000819
VI  - 10
IP  - 1
4099  - http://lupus.bmj.com/content/10/1/e000819.short
4100  - http://lupus.bmj.com/content/10/1/e000819.full
SO  - Lupus Sci Med2023 Mar 01; 10
AB  - Objective Lupus erythematosus (LE) is a complicated disease with highly heterogeneous clinical manifestations. Previous studies have rarely included all subgroups of patients with lupus and have overlooked the importance of the cutaneous manifestations thereof. We aimed to compare the demographic and clinical differences among patients with different subtypes of lupus.Methods This is the first real-world study with a relatively large sample size that simultaneously includes patients with isolated cutaneous lupus erythematosus (iCLE) and SLE. All samples were obtained from the Lupus Erythematosus Multicenter Case–control Study in Chinese populations (LEMCSC) (registration number: ChiCTR2100048939). Comparative analyses between different LE subgroups were performed.Results A total of 2097 patients with lupus were included, with 1865 patients with SLE, 1648 with cutaneous lupus erythematosus (CLE), and 232 with iCLE. Among the patients with CLE, 1330 had acute cutaneous lupus erythematosus (ACLE); 160 had subacute cutaneous lupus erythematosus (SCLE); and 546 had chronic cutaneous lupus erythematosus (CCLE). The study included a relatively large number of patients with CCLE subtypes, including 311 with discoid lupus erythematosus (DLE), 262 with chilblain lupus erythematosus (CHLE) and 45 with lupus erythematosus profundus (LEP). Demographic characteristics, systemic involvement, mucocutaneous manifestations and autoantibodies were significantly different among the groups.Conclusions CLE and iCLE are two distinct disease states, and the selection of broad or narrow CLE definitions should be emphasised in scientific reports. LE-non-specific cutaneous lesions imply more severity, while self-reported photosensitivity and LE-specific cutaneous manifestations imply milder severity. Generalised ACLE appears to be a more severe state than localised ACLE, and CHLE appears to be more severe than DLE. Anti-Sjögren’s syndrome-related antigen B (SSB) antibodies have higher specific directivity than anti-Sjögren’s syndrome-related antigen A (SSA) antibodies for SCLE lesions. Anti-double-stranded DNA antibodies have a higher co-occurrence with ACLE and a lower co-occurrence with SCLE and CCLE. Compared with DLE, CHLE has significantly higher positive rates of anti-SSA/Ro60 (71%) and anti-SSA/Ro52 (42.4%) antibodies, whereas LEP is associated with a higher positive rate of antinucleosome antibodies (31.1%).Data are available upon reasonable request. All data that support the findings of this study are available from the corresponding author on reasonable request.