RT Journal Article SR Electronic T1 LP-139 Baseline characteristics of a longitudinal, multinational, multiethnic study of lupus patients, with or without lupus nephritis JF Lupus Science & Medicine JO Lupus Sci Med FD Lupus Foundation of America SP A140 OP A141 DO 10.1136/lupus-2023-KCR.230 VO 10 IS Suppl 1 A1 Nieto, Romina A1 Quintana, Rosana A1 Borba, Eduardo F A1 Hernández, Lucia A1 Fernández-Ávila, Diana A1 Maurelli, Laura A1 Alba, Paula A1 Bordón, Florencia A1 Arizpe, Fernando A1 Berbotto, Guillermo A1 Serrano-Morales, Rosa A1 Bertolaccini, María Constanza A1 Kerzberg, Eduardo A1 de los Ángeles Gargiulo, María A1 Rodríguez, Anabella A1 Barbosa, Vitalina Sousa A1 Cavalcanti, Fernando A1 Alves Alvino, Laissa Cristina A1 Costa Seguro, Luciana Parente A1 De Oliveira Martins, Lucas Victoria A1 Neira, Oscar A1 Massardo, Loreto A1 Martínez, Gustavo Aroca A1 Aristizábal, Ivana Nieto A1 Paul, A A1 Gamarra, Antonio Iglesias A1 Vera, Andrés Zuñiga A1 lastra, Olga Vera A1 cristóbal, Mario Pérez A1 Martín-Nares, Eduardo A1 Amezcua-guerra, Luis A1 González-Bello, Yelitza A1 González Enriquez, José Octavio A1 Galarza-Delgado, Dionicio A1 Vázquez, Carolina Vázquez A1 Barrios, Marcelo A1 Linares, Magaly Alba A1 Reategui, Cristina A1 Quirós-alva, Ana Mabel A1 Polanco, Teresandris A1 Pizzarossa, Carina A1 Rebella, Martín A1 Crespo, María Elena A1 Danza, Álvaro A1 Bonfa, Eloisa A1 Alarcón, Graciela S A1 Zazzetti, Federico A1 Orillion, Ashley A1 Sbarigia, Urbano A1 Pons-Estel, Guillermo J YR 2023 UL http://lupus.bmj.com/content/10/Suppl_1/A140.3.abstract AB Background Clinically evident kidney disease eventually occurs in up to one-half of SLE patients. The aim of this study is to describe sociodemographic, clinical, serological and treatment characteristics of a multicenter and multiethnic Latin American SLE cohort of patients with or without lupus nephritis (LN).Methods GLADEL 2.0 is an ongoing observational cohort. Patients were categorized according to renal involvement: Group I (LN never); Group II (prevalent renal involvement currently inactive); Group III (prevalent renal involvement, currently active) and Group IV (incident renal involvement). Demographic, clinical manifestations, treatments, disease activity were examined at baseline. A descriptive cross-sectional analysis was performed.Results A total of 991 SLE patients were included, 884 (89.2%) female and 656 (68.3%) Mestizos (Amerindian and European ancestry). Median (IQR) age at cohort entry was 35 (28–45) years and disease duration were 67 months (18–139). Patients with incident LN had a higher proportion of males, were younger, had shorter disease duration and were more frequently Mestizos. Pericarditis and anti-dsDNA were less frequent in group I and MMF in groups I and IV (table 1). A predominance of class IV (49%) was evidenced in 510 patients in which a kidney biopsy was performed (349 prevalent LN and 161 incident LN).Conclusions Baseline characteristics of GLADEL 2.0 well characterized lupus patients’ cohort with or without LN are described with distinct demographic, clinical and laboratory patterns that will allow both centralized laboratory evaluation of urinary biomarkers and exploratory biomarker analyses including transcriptome and their impact on the outcome of these patients.View this table:Abstract LP-139 Table 1 Sociodemographic and clinical characteristics and treatment at cohort entry