Comparison of disease activity indices between PRI responders that met (n=58) or not (n=10) the SRI endpoint
| Baseline | PRI R/SRI R (n=58) Mean (SD) | PRI R/SRI non-R (n=10) Mean (SD) | p Value* |
|---|---|---|---|
| PGA | 1.7 (0.4) | 2.0 (0.5) | 0.042 |
| SLEDAI | 10.6 (4.5) | 8.9 (4.2) | 0.121 |
| Global BILAG | 15.4 (6.7) | 17.6 (8.4) | 0.497 |
| Number of BILAG domains (A, B, C) | 2.8 (0.9) | 2.6 (1.0) | 0.827 |
| Number of BILAG domains (A, B) | 1.7 (0.8) | 1.8 (0.9) | 0.883 |
| Follow-up | |||
| PGA | 0.7 (0.5) | 0.8 (0.5) | 0.388 |
| SLEDAI | 3.0 (3.2) | 7.0 (4.8) | 0.002 |
| Global BILAG | 4.3 (5.1) | 7.3 (6.3) | 0.084 |
| Number of BILAG domains (A, B, C) | 1.7 (1.0) | 2.0 (0.9) | 0.433 |
| Number of BILAG domains (A, B) | 0.4 (0.6) | 0.7 (0.8) | 0.165 |
*Mann–Whitney rank-sum test.
BILAG, British Isles Lupus Assessment Group; non-R, non-responders; PGA, physician's global assessment; PRI, physician-rated improvement; R, responders; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SRI, Systemic Lupus Responder Index.