Table 5

ORs and 95% CIs for adverse pregnancy outcomes in African-American SLE cases with antibody positivity

Antibody positivityStillbirth
OR (95% CI)
Spontaneous abortion
OR (95% CI)
Elective abortion
OR (95% CI)
Premature live birth
OR (95% CI)
Low birth weight
OR (95% CI)
Preeclampsia
OR (95% CI)
Any adverse outcome
OR (95% CI)
ds-DNAn=11
1.54 (0.53 to 4.50)
p=0.43
n=53
0.77 (0.50 to 1.19)
p=0.24
n=15
1.50 (0.60 to 3.75)
p=0.39
n=41
1.16 (0.67 to 1.99)
p=0.60
n=40
1.70 (0.93 to 3.12)
p=0.09
n=34
2.18 (1.07 to 4.43)
p=0.03
n=136
1.11 (0.79 to 1.55)
p=0.56
SSAn=4
0.98 (0.31 to 3.12)
p=0.98
n=27
1.14 (0.69 to 1.87)
p=0.61
n=6
1.18 (0.45 to 3.12)
p=0.74
n=25
2.27 (1.28 to 4.02)
p<0.01
n=22
2.12 (1.17 to 3.85)
p=0.01
n=15
1.61 (0.82 to 3.15)
p=0.17
n=66
1.47 (1.00 to 2.17)
p=0.053
SSBn=1
0.70 (0.09 to 5.41)
p=0.73
n=12
1.47 (0.73 to 2.95)
p=0.28
n=2
1.16 (0.26 to 5.19)
p=0.85
n=12
3.89 (1.77 to 8.58)
p<0.01
n=9
2.91 (1.24 to 6.82)
p=0.01
n=5
1.49 (0.54 to 4.12)
p=0.44
n=28
1.96 (1.09 to 3.53)
p=0.02
Lupus anticoagulantn=3
1.52 (0.41 to 5.71)
p=0.53
n=8
0.83 (0.37 to 1.88)
p=0.65
n=4
1.60 (0.50 to 5.11)
p=0.43
n=9
1.53 (0.66 to 3.51)
p=0.32
n=5
0.91 (0.33 to 2.53)
p=0.86
n=7
1.39 (0.56 to 3.47)
p=0.48
n=23
1.13 (0.63 to 2.03)
p=0.69
Anticardiolipin*n=2
0.69 (0.15 to 3.14)
p=0.63
n=18
1.22 (0.68 to 2.21)
p=0.51
n=3
0.90 (0.25 to 3.20)
p=0.87
n=6
0.52 (0.21 to 1.30)
p=0.16
n=4
0.43 (0.15 to 1.26)
p=0.12
n=2
0.21 (0.05 to 0.89)
p=0.03
n=28
0.69 (0.42 to 1.14)
p=0.14
Anti-β2GPI*n=2
1.52 (0.31 to 7.56)
p=0.61
n=3
0.40 (0.12 to 1.37)
p=0.14
n=1
0.61 (0.08 to 4.95)
p=0.64
n=3
0.63 (0.18 to 2.24)
p=0.47
n=5
1.70 (0.57 to 5.06)
p=0.34
n=4
1.53 (0.47 to 4.99)
p=0.48
n=11
0.73 (0.33 to 1.58)
p=0.42
Any SLE-related antibodyn=14
2.98 (0.67 to 13.31)
p=0.15
n=75
1.23 (0.75 to 2.01)
p=0.41
n=16
1.14 (0.44 to 2.97)
p=0.79
n=49
1.23 (0.68 to 2.24)
p=0.50
n=44
1.44 (0.75 to 2.80)
p=0.28
n=41
4.52 (1.58 to 12.91)
p<0.01
n=172
1.43 (0.98 to 2.08)
p=0.07
  • All estimates are unadjusted.

  • *Includes both low and high titres.

  • Anti-β2GPI, antibody to β2-glycoprotein I; SLE, systemic lupus erythematosus.