Genetics of systemic lupus erythematosus (SLE) for which thrombocytopenia was found to define or enhance the effect
| Author | No. of patients | Ethnicity | Gene (SNP) | Technique | Effect size |
|---|---|---|---|---|---|
| Scofield57 | 184 families* | North Am | 11p13 near CD44 | Genetic linkage | LOD score=3.71 in all LOD score=5.71 in AA |
| Trivedi154 | 252 | North Am | Osteopontin/rs11730582C | Candidate gene/SNP typing genetic association | OR=2.1 |
| Piotrowski63 | 199 | Poland | Monocyte chemoattractant protein 1/rs1024611 | Candidate gene/SNP typing genetic association | OR=2.62 |
| Amengual155 | 134 | Japan | Human platelet antigen 6 | Candidate gene/RFLP genetic association | OR=8.0 |
| Nolsoe156 | 126 families* | North Am | FAS and FAS ligand Codon214AC | Candidate gene/SNP typing transmission disequilibrium | p=0.006 |
| Namjou157 | 7490 | North Am | TRAF6/rs5030470 | Candidate gene/SNP typing genetic association | OR=0.57 |
| Jeon158 | 147 | Korea | IL-6 3′IL-6 33 | Candidate gene/VNTR K9 logistic regression inheritance models | p=0.02 |
| Jeon159 | 147 | Korea | IL-6/-278AC | Candidate gene/SNP typing genetic association | p=0.006 |
| Chan160 | 107 | Taiwan | Suppressor of cytokine signalling 1/-1478CA/del | Candidate gene/SNP typing dominant inheritance model | p=0.007 |
| Kim161 | 148 | Korea | C reactive protein/-390CA | Candidate gene/SNP typing genetic association | p=0.043 |
| Warchol162 | 102 | Poland | Catalase/-330CT | Candidate gene/RFLP typing recessive inheritance model for CC genotype | OR=7.4 p=0.0017 |
| Hong163 | 183 | Korea | FcgammaRIIIB/NA1/NA2 | Candidate gene/SNP typing genetic association | OR=2.4 p=0.04 |
*Families in these studies all had at least two patients with SLE.
AA, African–American; IL, interleukin; LOD, logarithm of odds; RFLP, restriction fragment length polymorphism; SNP, single-nucleotide polymorphism.