Table 2

Pregnancy loss rates by characteristics of the patients

Patient characteristicProportion (%) with pregnancy lossp Value*
All22/202 (11%)
Age (years)0.22
 <309/113 (8%)
 30–3910/83 (12%)
 40+3/6 (50%)
Ethnicity0.98
 Caucasian12/112 (11%)
 African–American8/68 (12%)
 Other2/22 (9%)
Year of conception0.069
 186–199913/78 (17%)
 2000–20045/42 (12%)
 2005+4/82 (5%)
Lupus anticoagulant measured in first trimester by dilute Russell viper venom time (confirm)0.0035
 Negative16/186 (9%)
 Positive6/16 (38%)
History of lupus anticoagulant by dilute Russell viper venom time prior to pregnancy0.95
 No18/167 (11%)
 Yes4/35 (11%)
Anticardiolipin IgG measured during first trimester†1.0†
 Normal9/108 (8%)
 High0/7 (0%)
Ever positive for anticardiolipin IgG0.66
 No7/74 (9%)
 Yes15/128 (12%)
Physician global assessment >2 during pregnancy0.0046
 No15/180 (8%)
 Yes6/21 (29%)
Low complement during first trimester0.049
 No8/118 (7%)
 Yes13/83 (16%)
Anti-dsDNA during first trimester0.19
 No12/140 (9%)
 Yes9/61 (15%)
Mean prednisone dose during first trimester0.093
 <1012/146 (8%)
 10+9/55 (16%)
History of thrombosis prior to pregnancy0.89
 No20/182 (11%)
 Yes2/20 (10%)
History of miscarriage prior to pregnancy0.28
 No12/132 (9%)
 Yes10/70 (14%)
Antiphospholipid syndrome‡ prior to pregnancy0.58
 No15/148 (10%)
 Yes7/54 (13%)
  • *Calculated based on a generalised estimating equation model to account for repeated pregnancies from the same woman.

  • †Calculated with Fisher's exact test.

  • ‡Defined as history of thrombosis or recurrent miscarriage and either history of lupus anticoagulant or elevated anticardiolipin.