Laboratory and histopathological characteristics at the time for repeat biopsy in clinical complete, partial and non-responders (all patients)
| CR (n=17) | PR (n=18) | NR (n=32) | p Value | |
|---|---|---|---|---|
| Anti-DNA IU/mL* | 34 (10–120) | 22 (7–250) | 45 (5–300) | 0.67 |
| C3, g/L | 0.81 (0.38–1.31) | 0.93 (0.6–1.38) | 0.72 (0.45–1.51) | 0.28 |
| C4, g/L | 0.12 (0.06–0.28) | 0.16 (0.1–0.45) | 0.13 (0.02–0.29) | 0.08 |
| Renal histology†, n | ||||
| Class I–II | 6 | 4 | 4 | |
| Class III/IV (C) | 6 | 3 | 5 | |
| Class III/IV (A) or (A/C) | 1 | 7 | 10 | |
| Class III/IV (A)+V | 0 | 0 | 2 | |
| Class V | 4 | 4 | 11 | |
| Activity index | 1 (0–3) | 2 (1–9) | 2 (0–12) | 0.001 |
| Chronicity index | 1 (0–6) | 3 (0–8) | 1.5 (0–8) | 0.26 |
| Histological response | ||||
| HR, n (%) | 12 (71) | 7 (39) | 9 (28) | |
| HNR, n (%) | 5 (29) | 11 (61)‡ | 23 (72) | |
All statistical significant p-values (p<0.05) are in italics. Values are presented as median (range) unless otherwise indicated.
*Available in 57 patients.
†According to the International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification.
‡Including the patient with a renal vasculitis on the repeat biopsy.
A, with active lesions; A/C, with both active and chronic lesions; C, with chronic lesions; C3, complement component 3; C4, complement component 4; CR, complete response; HNR, histopathological non-response; HR, histopathological response; n, number of patients; NR, non-response; PR, partial response.