Laboratory and histological findings at first and second biopsies in patients with eGFR>60 vs. eGFR<60 at long-term evaluation (median 10 years)
| eGFR>60, n=41 | eGFR<60, n=14 | ||||
|---|---|---|---|---|---|
| 1st biopsy | 2nd biopsy | 1st biopsy | 2nd biopsy | p Value | |
| Creatinine, µmol/l | 82 (52–185) | 75 (45–95) | 105 (52–176) | 86 (66–128) | ns <0.01 |
| Albuminuria, g/d | 1.4 (0.1–7.4) | 0.7 (0–3.4) | 2.2 (0–8.1) | 0.5 (0–3.6) | ns ns |
| Anti–DNA, IU/ml* | 200 (8–300) | 26.5 (<5–300) | 161 (13–300) | 16 (<5–170) | ns ns |
| C3, g/l | 0.44 (0.12–0.94) | 0.78 (0.4–1.41) | 0.5 (0.3–0.8) | 0.9 (0.38–1.51) | ns ns |
| C4, g/l | 0.07 (0.02–0.24) | 0.13 (0.03–0.3) | 0.11 (0.03–0.16) | 0.14 (0.04–0.26) | ns ns |
| Clinical response | |||||
| CR, n | 11 | 3 | ns | ||
| PR, n | 9 | 4 | ns | ||
| NR, n | 16 | 6 | ns | ||
| Nephritis class†, n | |||||
| I/II/III C | 16 | 5 | ns | ||
| III/IV A-A/C | 36 | 13 | 11 | 5 | ns |
| V | 6 | 12 | 3 | 3 | ns |
| HR, n | 16 | 6 | ns | ||
| HNR, n | 25 | 8 | ns | ||
| Activity index | 5 (0–13) | 2 (0–10) | 5 (1–13) | 1.5 (0–12) | ns ns |
| Chronicity index | 1 (0–6) | 1 (0–8) | 2 (0–6) | 3.5 (0–7) | ns 0.03 |
Values are presented as median (range) unless otherwise indicated.
*Available in 47 patients.
†According to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification.
C3, complement component 3; C4, complement component 4; CR, complete response; eGFR, estimated glomerular filtration rate; HNR, histopathological non-response.HR, histopathological response, NR, non-response; PR, partial response; ns, non-significant.