Table 1 Baseline

characteristics of cyclophosphamide (CYC) and enteric-coated mycophenolic sodium (EC-MPS) groups

Patients characteristicCYC (n=32)EC-MPS (n=27)
Female, n (%)32 (100)26 (96.3)
Age at enrolment (years; mean±SD)30.2±7.035.4±12.9
Median time (min–max) of lupus nephritis (months)46.5 (4.0–158.0)60.5 (3.0–240.0)
Systolic blood pressure (mm Hg; mean±SD)132±17136±19
Diastolic blood pressure (mm Hg; mean±SD)85±1687±14
Renal pathology, n (%)
 ISN/RPS class III10%4%
 ISN/RPS class IV90%96%
Relapse/resistant cases (%)34.4/65.637.0/63.0
Serum creatinine (mg/dL; mean±SD)0.90±0.420.99±0.40
eGFR by chronic kidney disease epidemiology (mL/min/1.73 m2; mean±SD)96.5±30.884.7±29.9
 Range of eGFR (mL/min/1.73 m2; n (%))
  ≥90 mL/min/1.73 m221 (65.6)15 (55.6)
  60–89 mL/min/1.73 m25 (15.6)4 (14.8)
  45–59 mL/min/1.73 m23 (9.4)4 (14.8)
  30–44 mL/min/1.73 m22 (6.3)3 (11.1)
  25–30 mL/min/1.73 m21 (3.1)1 (3.7)
Haemoglobin (g/dL; mean±SD)10.8±1.910.7±1.5
Haematocrit (%; mean±SD)33.1±5.432.6±4.5
Serum albumin (g/dL; mean±SD)2.88±0.722.68±0.69
Serum complement (mg/dL, mean±SD)
 C3 concentration72.1±35.271.8±32.6
 C4 concentration17±12.716.4±11.4
UPCR (mean±SD)7.5±5.39.0±6.1
Nephrotic-range proteinuria (≥3.5 g/day), n (%)22 (68.8)24 (88.9)
Urine red blood cell (cells/hpf; mean±SD)27.8±43.834.4±70.2
Urine white cell (cells/hpf; mean±SD)14.1±55.810.8±29.1
  • eGFR, estimated glomerular filtration rate; hpf, high-power field; ISN/RPS, International Society of Nephrology/Renal Pathology Society; UPCR, urine protein creatinine ratio (mg/mg).