Joint relationship between combinations of elevated IgG aCL and elevated RVVT and risk of thrombosis
| Antibody combinations | Subgroup* | No. of thromboses | No. of person-years | Rate (per 1000) | Rate ratios | p Value |
|---|---|---|---|---|---|---|
| aCL IgG RVVT | Neither elevated (n=1246) | 228 | 15 351 | 14.9 | 1.0 (Ref. group) | |
| Elevated IgG but not elevated RVVT (n=41) | 17 | 474 | 35.9 | 2.4 (1.4, 3.9) | 0.0006 | |
| Elevated RVVT but not elevated IgG (n=72) | 31 | 825 | 37.6 | 2.4 (1.7, 3.6) | <0.0001 | |
| Both elevated (n=31) | 8 | 376 | 21.3 | 1.4 (0.7, 2.8) | 0.36 |
*‘Elevated’ IgG means a geometric mean titre of ≥20. ‘Elevated’ RVVT means an RVVT of ≥45.
RVVT, dilute Russell's viper venom time.