Overall associations of categorised age at survey with summary health-related quality of life scores among patients with SLE in the Georgians Organized Against Lupus cohort, September 2013–November 2014
| Domain/model | Difference in score (95% CI), compared with age 20–39 years | |
|---|---|---|
| Age 40–59 years | Age ≥60 years | |
| Physical component summary (N=684) | ||
| Crude | −3.26 (−5.12 to −1.39) | −4.13 (−6.55 to −1.71) |
| Adjusted for SLE duration only | −3.28 (−5.21 to −1.35) | −4.18 (−6.80 to −1.56) |
| Multivariable-adjusted* | −2.53 (−4.38 to −0.67) | −3.57 (−6.19 to −0.96) |
| Multivariable+BILD score | −2.10 (−3.93 to −0.28) | −3.43 (−5.99 to −0.87) |
| Multivariable+SLAQ score | −2.15 (−3.87 to −0.43) | −3.13 (−5.55 to −0.71) |
| Multivariable+BILD and SLAQ score | −1.85 (−3.55 to −0.15) | −3.05 (−5.43 to −0.66) |
| Physical functioning (N=684) | ||
| Crude | −3.04 (−4.99 to −1.09) | −3.97 (−6.49 to −1.44) |
| Adjusted for SLE duration only | −3.09 (−5.11 to −1.07) | −4.07 (−6.80 to −1.33) |
| Multivariable-adjusted* | −2.12 (−4.04 to −0.19) | −3.42 (−6.13 to −0.72) |
| Multivariable+BILD score | −1.76 (−3.67 to 0.14) | −3.30 (−5.97 to −0.63) |
| Multivariable+SLAQ score | −1.76 (−3.57 to 0.05) | −3.01 (−5.55 to −0.47) |
| Multivariable+BILD and SLAQ score | −1.52 (−3.32 to 0.27) | −2.94 (−5.46 to −0.42) |
| Role physical (N=683) | ||
| Crude | −2.83 (−4.71 to −0.95) | −2.57 (−5.00 to −0.13) |
| Adjusted for SLE duration only | −3.09 (−5.04 to −1.15) | −3.10 (−5.74 to −0.47) |
| Multivariable-adjusted* | −2.05 (−3.90 to −0.19) | −2.58 (−5.18 to 0.02) |
| Multivariable+BILD score | −1.70 (−3.53 to 0.14) | −2.46 (−5.03 to 0.11) |
| Multivariable+SLAQ score | −1.67 (−3.38 to 0.04) | −2.13 (−4.53 to 0.27) |
| Multivariable+BILD and SLAQ score | −1.45 (−3.15 to 0.25) | −2.07 (−4.45 to 0.31) |
| Bodily pain (N=674) | ||
| Crude | −1.87 (−3.85 to 0.11) | −1.75 (−4.33 to 0.82) |
| Adjusted for SLE duration only | −1.88 (−3.93 to 0.17) | −1.77 (−4.57 to 1.02) |
| Multivariable-adjusted* | −0.88 (−2.83 to 1.07) | −1.70 (−4.45 to 1.05) |
| Multivariable+BILD score | −0.52 (−2.46 to 1.41) | −1.61 (−4.32 to 1.10) |
| Multivariable+SLAQ score | −0.34 (−2.07 to 1.40) | −1.15 (−3.60 to 1.29) |
| Multivariable+BILD and SLAQ score | −0.15 (−1.88 to 1.58) | −1.12 (−3.55 to 1.31) |
| General health (N=679) | ||
| Crude | −2.65 (−4.50 to −0.80) | −1.56 (−3.97 to 0.85) |
| Adjusted for SLE duration only | −2.80 (−4.72 to −0.89) | −1.87 (−4.48 to 0.74) |
| Multivariable-adjusted* | −2.14 (−4.03 to −0.25) | −1.63 (−4.29 to 1.03) |
| Multivariable+BILD score | −1.82 (−3.69 to 0.06) | −1.53 (−4.16 to 1.10) |
| Multivariable+SLAQ score | −1.71 (−3.44 to 0.01) | −1.15 (−3.58 to 1.27) |
| Multivariable+BILD and SLAQ score | −1.52 (−3.24 to 0.20) | −1.11 (−3.52 to 1.31) |
| Mental component summary (N=684) | ||
| Crude | −0.33 (−2.31 to 1.65) | 2.10 (−0.46 to 4.67) |
| Adjusted for SLE duration only | −0.73 (−2.77 to 1.32) | 1.29 (−1.48 to 4.07) |
| Multivariable-adjusted* | 0.47 (−1.46 to 2.41) | 1.20 (−1.52 to 3.92) |
| Multivariable+BILD score | 0.49 (−1.45 to 2.43) | 1.20 (−1.51 to 3.92) |
| Multivariable+SLAQ score | 0.86 (−0.94 to 2.65) | 1.65 (−0.87 to 4.17) |
| Multivariable+BILD and SLAQ score | 0.76 (−1.04 to 2.56) | 1.62 (−0.90 to 4.15) |
| Mental health (N=684) | ||
| Crude | −0.41 (−2.29 to 1.47) | 2.04 (−0.39 to 4.48) |
| Adjusted for SLE duration only | −0.76 (−2.70 to 1.18) | 1.32 (−1.31 to 3.96) |
| Multivariable-adjusted* | 0.50 (−1.35 to 2.35) | 1.36 (−1.25 to 3.96) |
| Multivariable+BILD score | 0.52 (−1.34 to 2.38) | 1.36 (−1.24 to 3.97) |
| Multivariable+SLAQ score | 0.87 (−0.84 to 2.59) | 1.79 (−0.62 to 4.20) |
| Multivariable+BILD and SLAQ score | 0.79 (−0.93 to 2.51) | 1.77 (−0.64 to 4.18) |
| Role emotional (N=681) | ||
| Crude | −1.62 (−3.94 to 0.71) | 0.14 (−2.87 to 3.16) |
| Adjusted for SLE duration only | −1.94 (−4.35 to 0.46) | −0.52 (−3.79 to 2.74) |
| Multivariable-adjusted* | −0.86 (−3.11 to 1.40) | −0.85 (−4.01 to 2.32) |
| Multivariable+BILD score | −0.69 (−2.95 to 1.57) | −0.79 (−3.95 to 2.37) |
| Multivariable+SLAQ score | −0.42 (−2.53 to 1.69) | −0.34 (−3.30 to 2.63) |
| Multivariable+BILD and SLAQ score | −0.38 (−2.50 to 1.74) | −0.33 (−3.30 to 2.64) |
| Social functioning (N=680) | ||
| Crude | −1.72 (−3.64 to 0.21) | −0.42 (−2.91 to 2.06) |
| Adjusted for SLE duration only | −1.91 (−3.90 to 0.08) | −0.82 (−3.52 to 1.88) |
| Multivariable-adjusted* | −0.71 (−2.62 to 1.21) | −0.50 (−3.19 to 2.18) |
| Multivariable+BILD score | −0.47 (−2.38 to 1.44) | −0.41 (−3.08 to 2.26) |
| Multivariable+SLAQ score | −0.26 (−1.99 to 1.46) | 0.01 (−2.41 to 2.43) |
| Multivariable+BILD and SLAQ score | −0.16 (−1.89 to 1.57) | 0.04 (−2.37 to 2.46) |
| Vitality (N=682) | ||
| Crude | −0.94 (−2.72 to 0.83) | −0.86 (−3.16 to 1.43) |
| Adjusted for SLE duration only | −1.33 (−3.16 to 0.50) | −1.66 (−4.15 to 0.82) |
| Multivariable-adjusted* | −0.51 (−2.34 to 1.33) | −1.25 (−3.83 to 1.33) |
| Multivariable+BILD score | −0.41 (−2.25 to 1.43) | −1.22 (−3.79 to 1.36) |
| Multivariable+SLAQ score | −0.19 (−1.92 to 1.54) | −0.84 (−3.27 to 1.59) |
| Multivariable+BILD and SLAQ score | −0.18 (−1.92 to 1.55) | −0.84 (−3.27 to 1.59) |
Complete case analysis was used (only individuals with complete information on the outcome and all covariates included). All subdomain scores are norm-based SF-12 scores.
*Adjusted for sex, race (African-American vs not African-American), employment, marital status, social support and lupus duration.
BILD, Brief Index of Lupus Damage; SLAQ, Systemic Lupus Activity Questionnaire; SLE, systemic lupus erythematosus.