Functioning by frailty classification: Cross-sectional and longitudinal analyses
| Cross-sectional, multivariate | Longitudinal, multivariate | ||||||
|---|---|---|---|---|---|---|---|
| Frailty index classification | VLA mean difficulty | SF-36 PF | Cognitiveimpairment | VLA mean difficulty | SF-36 PF | Cognitiveimpairment | |
| Robust (n = 42, 28%) | --- (reference) | ---(reference) | --- (reference) | --- (reference) | --- (reference) | --- (reference) | |
| Pre-frail (n = 66, 48%) | 0.32 (<0.0001 ) | −5.3 (0.0009) | 2.0 (0.6, 6.5) | 0.09 (0.07) | −2.1 (0.24) | 4.4 (0.4, 50.4) | |
| Frail (n = 30, 4%) | 0.65 (<0.0001 ) | − 11.7 (<0 .0001 †) | 4.4 (1.01, 19.6) | 0.32 (0.001) | −8.0 (0.002) | 26.2 (1.0, 716.4) | |
* p-value from analysis of variance For VLA and SF-36PF, values are beta (p-value) from multiple linear regression For cognitive impairment, values are odds ratio (95% confidence interval) from multiple logistic regression Cross-sectional multivariate analyses controlled for age, duration, low education, race, oral steroids, obesity, Systemic Lupus Activity Questionnaire (SLAQ), and Brief Index of Lupus Damage (BILD) Longitudinal analyses: Baseline frailty component/category predicting change in function 2 years later. Controlled for age, duration, low education, race, oral steroids, obesity, SLAQ, BILD, and baseline value of function