Multivariable cox proportional hazard model: Time-to-thrombosis
| Variable | HR | 95% CI: |
|---|---|---|
| Antimalarials* | 0.57 | 0.38–0.85 |
| Gender | 0.52 | 0.31–0.88 |
| Previous Thrombosis | 7.53 | 4.75–11.95 |
| Age at enrolment (Spline) | ||
| 5 years increase at 20 years | 0.92 | 0.81–1.04 |
| 5 years increase at 40 years | 1.07 | 0.98–1.18 |
| 5 years increase at 50 years | 1.67 | 1.12–2.35 |
| Corticosteroids Dose* | ||
| <7.5 mg/d vs. No | 0.81 | 0.36–1.84 |
| 7.5 – 15 mg/d vs. No | 1.00 | 0.46–2.16 |
| ≥15 – 60 mg/d vs. No | 1.56 | 0.79–3.05 |
| ≥60 mg/d vs. No | 3.15 | 1.43–6.94 |
| Hospitalizations* | 1.19 | 1.07–1.31 |
* Time dependent covariates.
**Variables considered as candidate for inclusion in the multivariable model but not selected in the final model were: ethnic group, medical coverage, hemolytic anaemia, renal disease, neurological disease, SLEDAI and SLICC-SDI at cohort enrolment and anticoagulant use (time-dependent).