Baseline demographic, clinical, and autoantibody profiles of anti-DFS 70 negative and positive patients and univariate and multivariate associations with anti-DFS70
| DFS-negative Mean or% n = 1056 | DFS-70 positive Mean or% n = 81 | Univariate model Odds ratio 95% CI: | Most informative multivariate model Odds ratio 95% CI: | |||
|---|---|---|---|---|---|---|
| Age at diagnosis, yr | 35.3 | 33.5 | 0.99 (0.97,1.01) | |||
| Female | 89.9 | 90.1 | 1.03 (0.48, 2.19) | |||
| Ethnicity Asian Black Hispanic White Other1 | 22.1 16.0 3.1 54.1 4.7 | 18.5 8.6 6.2 63.0 3.7 | 0.80 (0.45, 1.43) 0.50 (0.22, 1.10) 2.09 (0.79, 5.52) 1.44 (0.90, 2.30) 0.78 (0.24, 2.58) | |||
| Post-secondary education | 66.3 | 71.8 | 1.29 (0.78, 2.15) | |||
| Current smoker | 15.7 | 13.3 | 0.82 (0.41, 1.64) | |||
| Former smoker | 21.3 | 24.0 | 1.17 (0.67, 2.03) | |||
| Alcohol, F: >10/wk; M: >15/wk Hypertension, on meds | 1.5 27.5 | 1.3 26.3 | 0.86 (0.11, 6.58) 0.94 (0.56, 1.57) | |||
| Nephritis2 at enrollment | 29.5 | 21.3 | 0.65 (0.37, 1.15) | |||
| # ACR criteria | 4.8 | 4.6 | 0.89 (0.71, 1.12) | |||
| SLEDAI-2Kscore Neurological Mucocutaneous Musculoskeletal Renal Serositis Constitutional Immunological Hematological | 5.2 0.2 1.1 0.8 1.4 0.1 0.0 1.5 0.1 | 6.0 0.5 1.3 1.5 1.1 0.0 0.1 1.5 0.1 | 1.03 (0.99, 1.07) 1.08 (0.97, 1.21) 1.06 (0.95, 1.18) 1.24 (1.10, 1.40) 0.97 (0.89, 1.05) 0.58 (0.23, 1.48) 1.44 (0.50, 4.16) 0.99 (0.86, 1.14) 0.60 (0.25, 1.44) | 1.25 (1.10, 1.41) | ||
| Steroids,% ever using Antimalarials,% ever using Immunosuppressants, % ever using Biologics,% ever using | 80.3 73.3 43.0 0.76 | 80.2 77.8 37.0 0 | 1.00 (0.56, 1.76) 1.28 (0.74, 2.19) 0.78 (0.49, 1.24) | |||
| ANA | 93.8 | 93.8 | 1.01 (0.40 2.59) | |||
| DFS ANA by indirect immunofluorescence | 0.7 | 12.3 | ||||
| Anti-dsDNA | 40.1 | 26.3 | 0.53 (0.32, 0.89) | 0.53 (0.31, 0.92) | ||
| Autoantibodies | ||||||
| Monospecific DFS70 PCNA Ribosomal-P Ro52/TRIM21 SSA/Ro60 SSB/La Sm U1-RNP Lupus anticoagulant Anticardiolipin Anti-β2 glycoprotein1 | 0 6.9 15.7 35.4 46.3 16.0 23.9 31.5 6.6 12.5 14.3 | 16.0 8.6 11.1 27.2 34.6 4.9 16.0 21.0 7.4 12.3 24.7 | 1.27 (0.57, 2.87) 0.67 (0.33, 1.37) 0.68 (0.41, 1.13) 0.61 (0.38, 0.98) 0.27 (0.10, 0.75) 0.61 (0.33, 1.12) 0.58 (0.33, 1.0) 1.39 (0.81, 2.40) 0.98 (0.48, 2.03) 1.96 (1.12, 3.43) | 0.25 (0.08, 0.82) 2.15 (1.21, 3.84) | ||