Reproductive health by cyclophosphamide status and self-report of early secondary amenorrhoea
| Ever received cyclophosphamide | Never received cyclophosphamide | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Early secondary amenorrhoea | No early amenorrhoea | Early secondary amenorrhoea | No early amenorrhoea | |||||||
| N=12* | 43% (%) | N=16 | 57% (%) | p Value | N=17 | 17% (%) | N=85 | 83% (%) | p Value | |
| Pregnant ever | ||||||||||
| Yes | 7 | 64 | 15 | 94 | 0.13 | 15 | 88 | 77 | 91 | 0.67 |
| No | 4 | 36 | 1 | 6 | 2 | 12 | 8 | 9 | ||
| Pregnancies before lupus | ||||||||||
| 0 | 6 | 55 | 3 | 19 | 0.09 | 2 | 13 | 16 | 21 | 0.87 |
| 1 | 3 | 27 | 3 | 19 | 4 | 25 | 18 | 23 | ||
| ≥2 | 2 | 18 | 10 | 63 | 10 | 63 | 44 | 56 | ||
| Pregnancies after lupus | ||||||||||
| 0 | 7 | 70 | 10 | 71 | 0.67 | 11 | 65 | 44 | 59 | 0.16 |
| 1 | 2 | 20 | 1 | 7 | 5 | 29 | 13 | 17 | ||
| ≥2 | 1 | 10 | 3 | 21 | 1 | 6 | 18 | 24 | ||
| Total number of children | ||||||||||
| 0 | 5 | 45 | 2 | 14 | 0.34 | 5 | 29 | 10 | 13 | 0.17 |
| 1 | 4 | 36 | 7 | 50 | 4 | 16 | 14 | 18 | ||
| ≥2 | 2 | 18 | 6 | 36 | 8 | 47 | 52 | 68 | ||
| Children before lupus | ||||||||||
| 0 | 6 | 60 | 4 | 29 | 0.32 | 5 | 31 | 20 | 28 | 0.88 |
| 1 | 3 | 30 | 6 | 43 | 4 | 25 | 16 | 23 | ||
| ≥2 | 1 | 10 | 4 | 29 | 7 | 44 | 35 | 49 | ||
| Children after lupus | ||||||||||
| 0 | 9 | 82 | 12 | 86 | 1.00 | 13 | 76 | 48 | 63 | 0.67 |
| 1 | 1 | 9 | 1 | 7 | 2 | 12 | 17 | 22 | ||
| ≥2 | 1 | 9 | 1 | 7 | 2 | 12 | 11 | 14 | ||
*A number of women in each group had incomplete pregnancy data, so column totals represent the number of women with at least some pregnancy information but may not equal the total number of women in each outcome category.