Table 1

The baseline data including organs/systems involved and the treatment given to those patients treated with BCD

PatientAge of diagnosisFollow-up
EthnicitySymptom duration before diagnosis (weeks)Clinical features and serology at SLE diagnosisCYC post-BCDTAZA post-BCDTMMF post-BCDTAdditional RTX
1365Caucasian5Arthritis, fatigue, ANA, ↑ anti-dsDNA, lymphopenia, ↓ C3YesYesNoNo
2317Caucasian384Discoid lupus, malar rash, Raynaud's, alopecia, pleurisy, ↑ anti-dsDNA, lymphopeniaYesYesNoNo
3266Malaysian/Chinese16Discoid lupus, alopecia, Raynaud's, arthralgia, ANA, anti-SM, lymphopeniaNoYesNoNo
4396Caucasian40Arthritis, serosits, ANA, ↑ anti-dsDNA, lymphopenia, ↑aCLYesYesNoNo
5477African-Caribbean12Arthritis, rash, alopecia, ANA, lymphopeniaNoNoNoNo
6211Chinese4Rash, fever, angiooedema, arthritis, ANA, ↑ anti-dsDNA, lymphopenia, ↓ C3YesYesNoNo
7343African-Caribbean6Arthritis, rash, alopecia, ANA, lymphopeniaYesNoNoYes
8476African-Caribbean6Fever, fatigue, alopecia, rash, arthritis, serositis, ANA, anti-CCPYesYesNoNo
9445Caucasian4Livedo reticularis, serositis, rash, proteinuria, ANA, ↑ anti-dsDNA, lymphopenia, ↓ C3, ↑aCL and LAYesYesNoNo
10295African-Caribbean6Arthritis, rash, alopecia, ↑ anti-dsDNA, ↓ C3, ANA, RNPYesYesyesYes
11505Caucasian12Raynaud's, ANA, Ro, arthritis, mouth ulcers, photosensitivity, rash, Sjögren's syndromeYesYesNoYes
12261Caucasian20Arthritis, ANA, p-ANCA, ↑ anti-dsDNA, anti-SM, RNP, ↓ C3NoYesNoNo
13342Caucasian2Arthritis, ANA, rash, Sjögren's syndrome, ↑ anti-dsDNA, ↓ C3, renal failureYesNoyesNo
14256Caucasian8Arthritis, rash, fever, ANA, ↑ anti-dsDNA, anti-SM, RNP, ↓ C3YesNoyesYes
15282Asian4Arthritis, fatigue, fever, lymphadenopathy, ANA, pleurisy, Ro, LA, SM and RNP, ↓ C3YesYesNoNo
16326Caucasian2Arthritis, headache, Ro, LA, ANA, ↑ anti-dsDNAYesNoNoNo
  • aCL, antiocardiolipin antibody; ANCA, antineutrophil cytoplasmic antibody; AZA, azathioprine; BCD, B-cell depletion; BCDT, B-cell depletion treatment; CCP, cyclic citrullinated protein; CYC, cyclophosphamide; dsDNA, double-stranded DNA; LA, anti-La antibody; MMF, mycophenolate mofetil; RNP, anti-ribonucleic antibody; RTX, rituximab; SM, anti-Smith antibody.