Spearman rank correlation between metabolites in the kynurenine pathway and FSS in the entire SLE cohort and in the selection of patients with severe fatigue
| SLE patients (FSS=1–7) | SLE patients with severe fatigue (FSS 4–7) | |
| n=129 | n=100 | |
| Tryptophan | −0.034 (p=0.71) | 0.10 (p=0.34) |
| Kynurenine | 0.22 (p=0.01) | 0.34 (p=0.0006) |
| Quinolinic acid | 0.21 (p=0.02) | 0.28 (p=0.005) |
| Kynurenine/tryptophan | 0.25 (p=0.005) | 0.24 (p=0.02) |
| Quinolinic acid/kynurenine | −0.0046 (p=0.96) | −0.056 (p=0.58) |
Fatigue Severity Scale (FSS) data were obtained from 129 of 132 patients with SLE. Spearman’s correlation coefficients (rs ) above |0.2| are highlighted in bold.