Table 3

Spearman rank correlation between metabolites in the kynurenine pathway and FSS in the entire SLE cohort and in the selection of patients with severe fatigue

SLE patients (FSS=1–7)SLE patients with severe fatigue (FSS 4–7)
Tryptophan−0.034 (p=0.71)0.10 (p=0.34)
Kynurenine 0.22 (p=0.01) 0.34 (p=0.0006)
Quinolinic acid 0.21 (p=0.02) 0.28 (p=0.005)
Kynurenine/tryptophan 0.25 (p=0.005) 0.24 (p=0.02)
Quinolinic acid/kynurenine−0.0046 (p=0.96)−0.056 (p=0.58)
  • Fatigue Severity Scale (FSS) data were obtained from 129 of 132 patients with SLE. Spearman’s correlation coefficients (rs ) above |0.2| are highlighted in bold.