Predictors of transitions between SRI-5 response states
| Predictor | Non-response to response | Response to non-response | P values† | Logistic regression SRI-5 at 52 weeks (n=746) | |
| RR12 (95% CI)* | RR21 (95% CI)* | OR (95% CI) | P values‡ | ||
| Race | |||||
| White | 1 | 1 | 0.005 | 1 | 0.03 |
| Black | 0.83 (0.62 to 1.10) | 1.76 (1.23 to 2.52) | 0.61 (0.36 to 1.06) | ||
| Asian | 0.75 (0.59 to 0.95) | 1.29 (0.95 to 1.74) | 0.62 (0.38 to 1.02) | ||
| Native American | 0.96 (0.76 to 1.23) | 0.83 (0.58 to 1.18) | 1.31 (0.82 to 2.10) | ||
| Age (per 10 years increase) | 0.85 (0.78 to 0.92) | 0.88 (0.79 to 0.98) | <0.0001 | 0.93 (0.80 to 1.08) | 0.33 |
| Disease duration (per 10 years increase) | 1.00 (0.87 to 1.14) | 1.27 (1.07 to 1.51) | 0.025 | 0.80 (0.62 to 1.03) | 0.09 |
| SLEDAI (per 1 point increase) | 1.09 (1.06 to 1.11) | 0.88 (0.84 to 0.92) | <0.0001 | 1.11 (1.06 to 1.17) | <0.0001 |
| Anti-ds DNA (≥30 vs <30 IU/mL) | 1.09 (0.90 to 1.31) | 1.40 (1.07 to 1.81) | 0.039 | 1.20 (0.84 to 1.72) | 0.32 |
| Protein/creatinine ratio (>500 mg/g) | 2.20 (1.66 to 2.92) | 2.16 (1.51 to 3.10) | <0.0001 | 1.11 (0.60 to 2.05) | 0.74 |
| Lymphocyte count (per 1 unit increase) | 0.98 (0.86 to 1.11) | 0.72 (0.60 to 0.86) | 0.0008 | 1.28 (1.01 to 1.62) | 0.043 |
| Haemoglobin (per 1 unit increase) | 1.05 (0.99 to 1.11) | 0.90 (0.83 to 0.98) | 0.006 | 1.14 (1.01 to 1.28) | 0.032 |
| Anti-SSARo (per 10 units increase) | 1.02 (1.00 to 1.03) | 1.00 (0.98 to 1.02) | 0.044 | 1.01 (0.98 to 1.03) | 0.70 |
*RR ij =Rate ratio of transitioning from state i to j.
†Likelihood ratio test.
‡Wald test.
SLEDAI, SLE Disease Activity Index; SRI, SLE Responder Index.