Baseline cardiovascular measures of controls, low risk and newly identified high QRISK3 patients with SLE
| Variable | Controls (n=29) | Newly identified high QRISK3 patients* (n=21) | P values | Low-risk patients with SLE (n=80) | Newly identified high QRISK3 patients*(n=21) | P values |
| Age (years),mean±SD | 36.66±12.95 | 42.16±12.36 | 0.130 | 38.02±10.68 | 42.16±12.36 | 0.155 |
| Female | 29(100%) | 19(90%) | 0.420 | 78(97%) | 19(90%) | 0.507 |
| Ethnicity: Caucasian | 23(79%) | 13(62%) | 0.213 | 58(73%) | 13(62%) | 0.292 |
| BMI (kg/m2) | 22.6(21.3,25.3) | 31.8(24.3,37.0) | 0.003 | 25.3(22.2,28.4) | 31.8(24.3,37.0) | 0.026 |
| BP systolic (mm Hg) | 118.0(111.0,130.0) | 141.0(127.0,159.0) | 0.001 | 122.0(110.8,128.3) | 141.0(127.0,159.0) | < 0.001 |
| HDL cholesterol (mmol/L) | 1.7(1.5,2.0) | 1.5(1.3,1.8) | 0.037 | 1.7(1.2,2.0) | 1.5(1.3,1.8) | 0.222 |
| Non-HDL cholesterol (mmol/L) | 2.6(2.3,3.2) | 3.2(2.5,3.6) | 0.115 | 2.7(2.2,3.2) | 3.2(2.5,3.6) | 0.053 |
| Type 2 diabetes | 0(0%) | 3(14%) | 1.000 | 0(0%) | 3(14%) | 0.008 |
| Rheumatoid arthritis | 0(0%) | 0(0%) | 1.000 | 5(6%) | 0(0%) | 0.312 |
| Chronic kidney disease(stages3–5) | 0(0%) | 5(24%) | 0.010 | 3(4%) | 5(24%) | 0.021 |
| Migraines | 3(10%) | 1(5%) | 0.630 | 8(10%) | 1(5%) | 0.681 |
| Severe mental illness | 2(7%) | 2(9%) | 1.000 | 3(4%) | 2(9%) | 0.277 |
| Current smoker | 4(14%) | 6(29%) | 0.286 | 15(19%) | 6(29%) | 0.368 |
| Antihypertensive | 3(10.34%) | 15(71%) | < 0.001 | 13(16%) | 14(67%) | < 0.001 |
| Current oral corticosteroids | 0(0%) | 21(100%) | < 0.001 | 46(58%) | 21(100%) | < 0.001 |
Variables included in QRISK3 algorithm are shown; severe mental illness inclusive of depression, schizophrenia and bipolar disorder. Unless otherwise stated, values are shown as number (percentage) or median (lower, upper quartile). Data were analysed by Mann-Whitney U and Fisher’s exact tests as appropriate.
Bold type denotes p<0.05.
*Newly identified high QRISK3 patientsrefers to patients with SLEnewly identified as possessing high cardiovascular risk (≥10%) when using QRISK3 vsQRISK2. Patients with SLEidentified as high risk by both algorithms were not included in the analysis (n=8).
BMI, Body Mass Index;BP, blood pressure;HDL, high-density lipoprotein.