Abstract EF-04 Table 1

Association between cumulative average ultraviolet-B radiation and risk of incident SLE, overall and by subtypes characterized by anti-Ro/La antibodies (+Anti-Ro/La) and cutaneous manifestations, among participants in nurses’ health study and nurses’ health study II (1976–2014)

Cumulative Average Ultraviolet-B Radiation (mW/m2)
T1T2T3p-trend
SLE overall (n= 286)
Cases/Person-Years 86/22856321 97/20171088 103/25959040
MV-Adjusted HR (95% CI)a 1.00 (ref) 1.19 (0.89–1.60) 1.27 (0.94–1.70) 0.17
SLE with± Anti Ro/La (n= 38)
Cases/Person-Years 10/22855418 10/20169348 18/25958172
MV-Adjusted HR (95% CI)a 1.00 (ref) 0.99 (0.40–2.42) 1.75 (0.79–3.87) 0.10
SLE with Malar Rash (n= 131)
Cases/Person-Years 33/22855609 46/20169693 52/25958442
MV-Adjusted HR (95% CI)a 1.00 (ref) 1.44 (0.92–2.26) 1.68 (1.08 – 2.62) 0.04
SLE with Photosensitivity (n= 164)
Cases/Person-Years 49/22855817 57/20170566 58/25958484
MV-Adjusted HR (95% CI)a 1.00 (ref) 1.23 (0.83–1.81) 1.29 (0.87–1.90) 0.29
SLE with± Anti Ro/La and/or Malar Rash and/or Photosensitivity (n= 224)
Cases/Person-Years 64/22856035 75/20170825 85/25958826
MV-Adjusted HR (95% CI)a 1.00 (ref) 1.24 (0.89–1.75) 1.44 (1.03 – 2.00) 0.05

  • Tertiles T1 (lowest), T2 (middle), T3 (highest). Tertile range: T1: 2–171 mW/m2 ; T2: 171–183 mW/m2; T3:183–285 mW/m2.

  • aAdjusted for age (months), race (white, non-white), questionnaire cycle, cohort, body mass index (20 to <25, 25 to <30,>30), cigarette smoking (never/past/current), alcohol intake (0,>0 to<5 grams per day)

  • HR=hazard ratio; CI=confidence interval; MV=multivariable; P-trend derived by treating median value of each category as a continuous variable

  • p for heterogeneity between the cohorts>0.05 for all analyses