Pooled odds ratios for the association of hydroxychloroquine use and pregnancy outcomes
| Fetal Loss | Preterm Birth | High Disease Activity | Preeclampsia | |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Overall | 0.50 (0.27 – 0.94) | 0.95 (0.58–1.55) | 0.69 (0.35–1.39) | 1.19 (0.62–2.30) |
| Lupus Nephritis History | 0.24 (0.07 – 0.83) | 0.81 (0.35–1.89) | 0.47 (0.21–1.09) | 0.70 (0.24–2.03) |
| No Lupus Nephritis History | 0.70 (0.33–1.46) | 1.04 (0.57–1.89) | 0.98 (0.45–2.17) | 1.36 (0.58–3.16) |
| APS | 0.39 (0.10–1.47) | 0.82 (0.23–2.96) | 1.30 (0.16–10.48) | 0.55 (0.12–2.45) |
| No APS | 0.61 (0.31–1.20) | 0.96 (0.56–1.64) | 0.70 (0.40–1.22) | 1.28 (0.58–2.84) |
| High Disease Activity at 1st Visit | 0.61 (0.13–2.89) | 1.53 (0.42–5.62) | -- | 0.93 (0.12–7.14) |
| No High Disease Activity at 1st Visit | 0.46 (0.21–1.02) | 0.81 (0.45–1.44) | 0.73 (0.29–1.87) | 1.07 (0.50–2.31) |