Table 1

Comparison of miRNA dysregulation in human and MRL/lpr lupus PBMCs, and in MRL/lpr lupus splenocytes

microRNAsHuman lupus PBMCsMouse lupus PBMCsMouse lupus splenocytes
miR-21Upregulated18 20 21 UpregulatedUpregulated
miR-31Downregulated22 29 UpregulatedUpregulated16
miR-127Upregulated18 UpregulatedUpregulated16 19
miR-146aUpregulated,18 downregulated22 40 UpregulatedNo change16
miR-148aUpregulated18 21 No changeUpregulated
miR-155Upregulated18 21 UpregulatedUpregulated16
miR-96NDUpregulatedUpregulated16
miR-182Upregulated18 UpregulatedUpregulated16
miR-183NDUpregulatedUpregulated16
miR-411NDUpregulatedUpregulated19

  • ND, no data; PBMCs, peripheral blood mononuclear cells.