Table 3

Logistic regression for the association with a ‘high risk’ PREDICTS score* at 12-week follow-up

Explanatory variableOR95% CIP value
Initiating MMF therapy0.0020.000 to0.550.03
Initiating AZA therapy0.190.01 to 4.1ns
Total prednisone (mg) 0–12weeks1.01.000 to1.0010.04
% Change in SLEDAI 0–12weeks14.62.0 to106.10.008
Gender0.190.00 to 5.15E+17ns
Race/ethnicity1.30.54 to 3.3ns
Number of PREDICTS variables present at baseline136.64.0 to4695.70.006
  • *Includes age ≥48 years, piHDL ≥0.94 FU, leptin≥34 ng/mL, sTWEAK ≥373 pg/mL, homocysteine ≥12 mmol/L; high PREDICTS defined as ≥3 factors or diabetes+1 PREDICTS factor.

  • AZA, azathioprine; MMF, mycophenolate mofetil; SLEDAI, SLE Disease Activity Index; piHDL, proinflammatory high-density lipoprotein; sTWEAK, soluble tumour necrosis factor-like weak inducer of apoptosis.