Table 3

Brain regions with significant differences in metabolic activity between 8 SNT+ SLE and 11 SNT− SLE subjects

Brain regionCoordinates†
xyzZmaxOne-way ANOVA
F, P value
IHC (n=25)SLE
SNT+
(n=8)
SLE SNT− (n=11)
Metabolic Increases in SNT+ SLE compared with SNT− SLE
Anterior putamen/caudate, left−20−2123.9910.08, 0.00031.37 (0.07)§1.48 (0.04)+++***1.36 (0.06)
Anterior putamen, right222123.626.02, 0.00511.43 (0.09)1.52 (0.07)++*1.40 (0.06)
Prefrontal cortex/BA 9, left−3424283.30#9.32, 0.00051.60 (0.10)1.76 (0.13)+++**1.58 (0.08)
Prefrontal cortex/BA 9, right3814364.065.82, 0.00591.66 (0.14)1.73 (0.07)++1.56 (0.06)*
Prefrontal cortex/BA 10, right1442163.92##13.74, <0.00011.55 (0.05)1.61 (0.05)+++*1.49 (0.06)**
Lateral frontal cortex/BA 8, left−368444.32#10.82, 0.00021.78 (0.09)1.89 (0.04)+++*1.70 (0.09)
Medial frontal cortex/BA 8, left−1030524.03#13.27, <0.00011.68 (0.05)1.78 (0.05)+++***1.66 (0.05)
  • +P<0.05, ++p<0.01, +++p<0.001, post hoc Bonferroni tests of SLE SNT+ subjects versus SLE SNT− subjects.

  • *P<0.05, **p<0.01, ***p<0.001, post hoc Bonferroni tests of SLE SNT+ or SNT− subjects versus IHC group.

  • #P<0.05, ##p<0.01, corrected for cluster extent, SPM analysis of SLE SNT+ subjects versus SLE SNT− subjects.

  • †Montreal Neurological Institute (MNI) standard space56

  • ‡Significant at p<0.001 (peak voxel, uncorrected), SPM analysis of SLE SNT+ subjects versus SLE SNT− subjects.

  • §Mean (SD) regional metabolism.

  • BA, Brodmann area;IHC, imaging healthy controls; SNT+/SNT−, SLE subjects completed/failed the spatial navigation task.