Table 4

Univariate regressions for GlycA and hsCRP

ParameterGlycA (n=64)hsCRP (n=63)
Demographic and clinical characteristics
 Age0.013 (0.901)0.199 (0.118)
 Gender0.011 (0.934)0.090 (0.485)
 Smoking, N (%)0.240 (0.060)0.534 (<0.001)
Clinical and laboratory values
 BMI, kg/m20.328 (0.008)0.221 (0.081)
 Systolic BP, mm Hg0.033 (0.794)0.052 (0.687)
 Diastolic BP, mm Hg0.023 (0.854)−0.155 (0.225)
 Total cholesterol, mg/dL−0.008 (0.950)−0.127 (0.322)
 LDL, mg/dL0.008 (0.952)−0.051 (0.695)
 HDL, mg/dL−0.139 (0.272)−0.226 (0.075)
 Triglycerides, mg/dL0.187 (0.143)0.043 (0.739)
 Framingham Risk Score0.040 (0.752)0.310 (0.013)
 HOMA-IR0.407 (0.001)0.234 (0.065)
 Glucose, mg/dL0.270 (0.031)0.093 (0.470)
 Insulin, mcU/ml0.433 (<0.001)0.247 (0.051)
 Erythrocyte sedimentation rate, mm/hour0.611 (<0.001)0.284 (0.025)
 High-sensitivity C reactive protein, mg/L0.578 (<0.001)
 Protein/creatinine ratio0.226 (0.097)−0.071 (0.611)
 WBC count0.441 (<0.001)0.233 (0.068)
SLE characteristics
 SLEDAI0.011 (0.934)0.043 (0.740)
 SLICC0.331 (0.010)0.293 (0.024)
 Disease duration, years0.226 (0.073)0.456 (<0.001)
 Hydroxychloroquine, N (%)0.079 (0.533)0.026 (0.841)
 Azathioprine, N (%)0.205 (0.104)−0.092 (0.471)
 Methotrexate, N (%)−0.187 (0.140)−0.014 (0.911)
 Mycophenolate mofetil, N (%)−0.043 (0.735)−0.114 (0.372)
 Cumulative 20-day steroid dose, mg0.410 (0.016)−0.178 (0.314)
Coronary plaque burden
 Total burden, (× 100) mm20.217 (0.027)−0.131 (0.184)
 Calcified burden, (× 100) mm20.092 (0.355)−0.077 (0.438)
 Non-calcified burden, (×100) mm20.198 (0.044)−0.117 (0.238)
  • Univariate regressions reported as β-coefficient (p value).

  • Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain statistically significant.

  • BMI, body mass index; GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; HOMA-IR, homoeostatic model assessment insulin resistance; LDL, low-density lipoprotein; SLEDAI, SLE Disease Activity Index; SLICC, Systemic Lupus International Collaborating Committee; WBC, white blood cell count; hsCRP, high-sensitivity C reactive protein.