Table 2

Lipoprotein particle subfractions and GlycA in SLE and healthy controls as assessed by NMR

LipoproteinsSLE (n=64)Control (n=30)P values
Baseline parameters
 Total cholesterol, mg/dL163.5 (148–191)164.0 (145–202)0.764
 Triglycerides, mg/dL86.5 (67–123)77.0 (61–91)0.131
 HDL cholesterol, mg/dL54.1±1666.9±16<0.001
 LDL cholesterol, mg/dL99.0 (84–124)85.5 (72–125)0.359
 VLDL triglycerides, mg/dL59.9 (44–87)47.8 (36–58)0.031
 GlycA405.0 (365–470)357.5 (301–411)0.001
Particle counts
 HDL particle count, umol/L30.0±5.935.0±7.7<0.001
 Small HDL particle count, umol/L12.7±7.710.1±6.70.057
 Medium HDL particle count, umol/L8.1 (4–12)14.2 (9–21)<0.001
 Large HDL particle count, umol/L6.9 (5–10)10.5 (9–12)0.001
 LDL particle count, nmol/L1094.0 (871–1220)843.5 (675–1219)0.029
 Small LDL particle count, nmol/L419.5 (211–653)271.0 (0–389)0.027
 Large LDL particle count, nmol/L419.5 (317–577)445.0 (249–687)0.805
 IDL particle count, nmol/L53.5 (25–124)130.5 (62–190)0.001
 VLDL particle count, nmol/L41.1 (29–61)33.3 (21–47)0.067
 Small VLDL particle count, nmol/L26.6 (18–38)20.8 (14–34)0.192
 Medium VLDL particle count, nmol/L13.5 (7–25)6.8 (2–14)0.007
 Large medium VLDL particle count, nmol/L14.7 (7–27)8.7 (3.7–15.1)0.017
 Large VLDL particle count, nmol/L2.3 (1.2–4.1)1.8 (1.3–3.7)0.961
Particle Size
 HDL particle size, nm9.6 (9.1–9.9)9.9 (9.5–10.1)0.013
 LDL particle size, nm21.0 (20.4–21.4)21.1 (20.7–21.6)0.295
 VLDL particle size, nm47.6 (43–51)48.5 (45–54)0.441
  • Student's t-test used unless otherwise noted (mean±SD).

  • Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain significant.

  • *Mann-Whitney test used (median (IQR)).

  • GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NMR, nuclear MR; VLDL, very low-density lipoprotein.