Univariate regressions of NMR parameters and medications
| NMR parameters | Prednisone (n=64) | 20-day prednisone dose (n=34) | Hydroxychloroquine (n=64) | Statins (n=64) |
| Baseline parameters | ||||
| Total cholesterol | 0.045 (0.724) | 0.243 (0.166) | 0.082 (0.519) | −0.042 (0.740) |
| Triglycerides | 0.143 (0.261) | 0.405 (0.018) | 0.178 (0.160) | −0.133 (0.294) |
| HDL cholesterol | 0.048 (0.707) | −0.021 (0.904) | 0.009 (0.946) | 0.123 (0.333) |
| LDL cholesterol | 0.013 (0.918) | 0.333 (0.054) | 0.078 (0.542) | −0.107 (0.398) |
| VLDL triglycerides | 0.162 (0.200) | 0.430 (0.011) | 0.172 (0.174) | −0.150 (0.236) |
| GlycA | 0.214 (0.089) | 0.410 (0.016) | 0.079 (0.553) | 0.133 (0.294) |
| Particle counts | ||||
| HDL particle count | −0.217 (0.086) | −0.206 (0.243) | −0.067 (0.596) | 0.136 (0.285) |
| Small HDL particle count | −0.236 (0.060) | 0.049 (0.784) | −0.111 (0.384) | −0.034 (0.790) |
| Medium HDL particle count | −0.079 (0.536) | −0.374 (0.029) | 0.033 (0.795) | 0.104 (0.415) |
| Large HDL particle count | 0.200 (0.112) | 0.048 (0.787) | 0.050 (0.694) | 0.121 (0.341) |
| LDL particle count | −0.050 (0.694) | 0.321 (0.065) | 0.046 (0.717) | −0.135 (0.289) |
| Small LDL particle count | −0.114 (0.370) | 0.025 (0.889) | −0.027 (0.834) | −0.088 (0.488) |
| Large LDL particle count | 0.046 (0.716) | 0.338 (0.050) | 0.112 (0.380) | −0.038 (0.764) |
| IDL particle count | 0.124 (0.327) | 0.011 (0.951) | −0.028 (0.826) | −0.083 (0.516) |
| VLDL particle count | 0.179 (0.157) | 0.468 (0.005) | 0.115 (0.365) | −0.114 (0.368) |
| Small VLDL particle count | 0.136 (0.283) | 0.340 (0.049) | 0.093 (0.467) | −0.027 (0.831) |
| Medium VLDL particle count | 0.172 (0.173) | 0.419 (0.014) | 0.074 (0.561) | −0.162 (0.202) |
| Large medium VLDL particle count | 0.156 (0.219) | 0.424 (0.013) | 0.095 (0.453) | −0.161 (0.203) |
| Large VLDL particle count | 0.033 (0.793) | 0.194 (0.271) | 0.183 (0.149) | −0.048 (0.706) |
| Particle size | ||||
| HDL particle size | 0.184 (0.147) | −0.063 (0.725) | 0.036 (0.778) | 0.069 (0.588) |
| LDL particle size | 0.063 (0.619) | 0.003 (0.985) | 0.121 (0.342) | 0.086 (0.498) |
| VLDL particle size | 0.094 (0.459) | 0.112 (0.529) | 0.081 (0.523) | 0.022 (0.863) |
Univariate regressions reported as β-coefficient (p value).
Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain statistically significant.
GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NMR, nuclear MR; VLDL, very low-density lipoprotein.