Table 5

Univariate regressions of NMR parameters and lupus history

NMR parametersSLEDAI (n=63)SLICC (n=59)Disease duration (n=64)Protein/
creatinine ratio (n=55)
Framingham
risk (n=64)
HOMA-IR (n=64)
Baseline parameters
 Total cholesterol0.250 (0.049)−0.072 (0.586)−0.084 (0.509)0.111 (0.419)0.030 (0.814)−0.011 (0.928)
 Triglycerides−0.008 (0.951)−0.075 (0.570)−0.095 (0.454)0.236 (0.083)0.138 (0.277)0.453 (<0.001)
 HDL cholesterol−0.231 (0.069)−0.134 (0.312)−0.021 (0.868)−0.019 (0.890)−0.237 (0.059)0.315 (0.011)
 LDL cholesterol−0.144 (0.260)−0.017 (0.900)−0.084 (0.509)0.050 (0.715)0.313 (0.301)−0.013 (0.917)
 VLDL triglycerides0.057 (0.657)−0.059 (0.660)−0.123 (0.332)0.280 (0.038)0.097 (0.445)0.521 (<0.001)
 GlycA0.011 (0.934)0.331 (0.010)0.226 (0.073)0.226 (0.097)0.040 (0.752)0.407 (0.001)
Particle counts
HDL particle count0.345 (0.006)−0.197 (0.135)0.001 (0.999)0.048 (0.728)0.002 (0.990)−0.103 (0.418)
 Small HDL particle count0.281 (0.026)0.012 (0.927)−0.107 (0.402)0.101 (0.461)0.132 (0.300)0.144 (0.257)
 Medium HDL particle count0.051 (0.691)−0.155 (0.241)0.178 (0.159)−0.043 (0.753)0.046 (0.721)−0.038 (0.767)
 Large HDL particle count−0.085 (0.509)−0.106 (0.424)−0.046 (0.719)−0.054 (0.694)0.286 (0.022)0.350 (0.005)
LDL particle count−0.029 (0.822)−0.036 (0.787)−0.127 (0.318)0.109 (0.429)0.332 (0.007)0.180 (0.154)
 Small LDL particle count0.127 (0.320)−0.049 (0.712)−0.036 (0.779)0.094 (0.496)0.403 (0.001)0.314 (0.012)
 Large LDL particle count−0.162 (0.203)0.010 (0.942)−0.154 (0.225)0.044 (0.748)−0.073 (0.567)−0.158 (0.214)
IDL particle count−0.130 (0.308)0.005 (0.971)0.083 (0.517)−0.104 (0.451)−0.104 (0.413)−0.083 (0.515)
VLDL particle count0.048 (0.711)−0.013 (0.924)−0.170 (0.179)0.436 (0.001)0.013 (0.918)0.534 (<0.001)
 Small VLDL particle count0.044 (0.730)0.051 (0.699)−0.165 (0.193)0.498 (<0.001)−0.078 (0.542)0.414 (<0.001)
 Medium VLDL particle count0.016 (0.902)−0.069 (0.605)−0.101 (0.428)0.256 (0.059)0.069 (0.587)0.421 (<0.001)
 Large medium VLDL particle count0.033 (0.797)−0.074 (0.578)−0.112 (0.380)0.247 (0.069)0.102 (0.424)0.457 (<0.001)
Large VLDL particle count0.084 (0.515)−0.013 (0.921)−0.066 (0.605)0.068 (0.622)0.194 (0.125)0.414 (0.001)
Particle size
 HDL particle size0.011 (0.932)−0.078 (0.557)0.056 (0.659)−0.081 (0.554)0.329 (0.008)0.353 (0.004)
 LDL particle size−0.191 (0.133)0.030 (0.821)0.151 (0.237)−0.129 (0.347)0.267 (0.033)0.316 (0.011)
 VLDL particle size−0.073 (0.569)−0.036 (0.789)0.067 (0.600)−0.182 (0.185)0.740 (0.580)−0.003 (0.979)
  • Univariate regressions reported as β-coefficient (p value).

  • Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain statistically significant.

  • GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; HOMA-IR, homoeostatic model assessment insulin resistance; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NMR, nuclear MR; SLEDAI, SLE Disease Activity Index; SLICC, Systemic Lupus International Collaborating Committee; VLDL, very low-density lipoprotein.