Model | HDL cholesterol | HDL particle size | Small HDL particle count | Medium HDL particle count | Large HDL particle count | Large VLDL particle count | VLDL particle size | GlycA |
Unadjusted | −0.331 (0.001) | −0.226 (0.021) | 0.231 (0.019) | −0.214 (0.029) | −0.292 (0.003) | 0.278 (0.004) | 0.283 (0.004) | 0.198 (0.044) |
Model 1 | −0.330 (0.001) | −0.226 (0.022) | 0.230 (0.019) | −0.216 (0.027) | −0.291 (0.003) | 0.278 (0.005) | 0.281 (0.002) | 0.199 (0.044) |
Model 2 | −0.328 (0.001) | −0.260 (0.009) | 0.290 (0.003) | −0.250 (0.011) | −0.304 (0.002) | 0.284 (0.005) | 0.248 (0.008) | 0.143 (0.138) |
Model 3 | −0.344 (0.008) | 0.026 (0.828) | −0.040 (0.722) | −0.239 (0.067) | −0.183 (0.149) | 0.379 (0.004) | 0.220 (0.071) | 0.122 (0.338) |
Model 4 | −0.353 (<0.001) | −0.242 (0.013) | 0.233 (0.018) | −0.222 (0.024) | −0.310 (0.001) | 0.279 (0.004) | 0.292 (0.003) | 0.195 (0.047) |
Model 5 | −0.319 (0.001) | −0.141 (0.151) | 0.187 (0.072) | −0.193 (0.039) | −0.259 (0.009) | 0.214 (0.024) | 0.309 (0.001) | 0.042 (0.696) |
Model 6 | −0.337 (0.002) | −0.172 (0.138) | 0.221 (0.050) | −0.183 (0.132) | −0.301 (0.008) | 0.231 (0.04) | 0.298 (0.007) | 0.138 (0.320) |
Model 7 | −0.305 (0.010) | −0.055 (0.628) | 0.148 (0.202) | −0.167 (0.149) | −0.232 (0.045) | 0.180 (0.098) | 0.324 (0.002) | −0.042 (0.775) |
Model 8 | −0.440 (<0.001) | −0.073 (0.534) | 0.063 (0.586) | −0.146 (0.222) | −0.307 (0.010) | 0.222 (0.035) | 0.318 (0.002) | 0.018 (0.901) |
Model 9 | −0.477 (<0.001) | −0.089 (0.479) | 0.070 (0.560) | −0.142 (0.214) | −0.323 (0.006) | 0.225 (0.035) | 0.334 (0.001) | – |
Model 10 | – | – | – | – | – | – | – | 0.214 (0.024) |
Model 1 – adjusted for ethnicity.
Model 2 – adjusted for ethnicity + race.
Model 3 – adjusted for ethnicity + race + BMI.
Model 4 – adjusted for Framingham risk.
Model 5 – adjusted for Framingham risk + HOMA-IR.
Model 6 – adjusted for Framingham risk + 20-day prednisone dose.
Model 7 – adjusted for Framingham risk + HOMA-IR + 20-day prednisone dose.
Model 8– adjusted for Framingham risk + HOMA-IR + 20-day prednisone dose + SLEDAI.
Model 9 – adjusted for Framingham risk + HOMA-IR + 20-day prednisone dose + SLEDAI + GlycA.
Model 10 – adjusted for HDL cholesterol + HDL particle size + small HDL particle count + medium HDL particle count + large HDL particle count + large VLDL particle count + VLDL particle size.
Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain statistically significant.
BMI, body mass index; GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; HOMA-IR, homoeostatic model assessment insulin resistance; SLEDAI, SLE Disease Activity Index; VLDL, very high-density lipoprotein.