Table 6

Univariate regressions of NMR parameters and autoantibodies

NMR ParametersC3 (n=63)C4 (n=63)anti-dsDNA (n=63)anti-ENA (n=62)Ro (n=60)La (n=60)Sm (n=60)CCP (n=21)RNP (n=60)
Baseline parameters
 Total cholesterol0.050 (0.697)0.027 (0.836)−0.059 (0.648)0.051 (0.695)−0.096 (0.467)−0.098 (0.457)−0.030 (0.820)−0.210 (0.360)−0.032 (0.810)
 Triglycerides−0.116 (0.367)−0.140 (0.273)0.125 (0.330)0.011 (0.931)0.014 (0.914)−0.081 (0.540)−0.037 (0.778)−0.220 (0.338)−0.082 (0.535)
 HDL cholesterol−0.167 (0.192)−0.004 (0.974)−0.230 (0.069)−0.236 (0.065)−0.112 (0.394)−0.218 (0.094)0.029 (0.827)−0.137 (0.554)−0.174 (0.184)
 LDL cholesterol0.159 (0.214)0.140 (0.274)−0.033 (0.795)0.089 (0.493)−0.153 (0.243)−0.054 (0.681)−0.076 (0.562)−0.290 (0.202)0.025 (0.849)
 VLDL triglycerides−0.115 (0.371)−0.144 (0.262)0.158 (0.216)0.026 (0.844)0.049 (0.710)−0.033 (0.801)−0.035 (0.793)−0.193 (0.402)−0.091 (0.489)
 GlycA0.287 (0.022)0.166 (0.193)0.045 (0.728)0.064 (0.623)0.005 (0.973)0.180 (0.170)−0.005 (0.969)−0.171 (0.460)−0.006 (0.964)
Particle counts
 HDL particle count0.195 (0.125)0.220 (0.083)0.264 (0.037)0.273 (0.032)−0.093 (0.482)−0.155 (0.238)−0.046 (0.724)−0.259 (0.257)0.295 (0.022)
 Small HDL particle count0.377 (0.002)0.259 (0.040)0.057 (0.665)0.056 (0.667)0.064 (0.627)−0.056 (0.669)0.039 (0.766)−0.276 (0.225)−0.036 (0.788)
 Medium HDL particle count−0.021 (0.871)−0.001 (0.992)−0.273 (0.031)−0.221 (0.085)−0.101 (0.445)0.117 (0.375)−0.141 (0.281)0.084 (0.717)−0.185 (0.157)
 Large HDL particle count0.333 (0.008)−0.123 (0.336)−0.127 (0.323)−0.207 (0.106)−0.108 (0.412)0.262 (0.043)0.048 (0.714)−0.017 (0.941)−0.106 (0.421)
 LDL particle count0.332 (0.008)0.180 (0.158)0.091 (0.476)0.169 (0.189)−0.090 (0.495)0.002 (0.991)−0.085 (0.520)−0.143 (0.537)0.114 (0.387)
 Small LDL particle count0.320 (0.010)0.106 (0.409)0.227 (0.074)0.108 (0.405)0.008 (0.953)0.043 (0.742)−0.061 (0.643)0.008 (0.973)0.099 (0.451)
 Large LDL particle count0.039 (0.760)0.104 (0.415)−0.130 (0.311)0.057 (0.657)−0.082 (0.533)−0.041 (0.756)−0.035 (0.788)−0.236 (0.304)0.022 (0.865)
 IDL particle count−0.153 (0.232)−0.060 (0.641)−0.174 (0.171)0.056 (0.664)−0.134 (0.309)−0.037 (0.781)0.041 (0.754)0.001 (0.998)−0.063 (0.631)
 VLDL particle count−0.127 (0.322)−0.126 (0.325)0.123 (0.339)0.087 (0.500)0.146 (0.265)0.005 (0.970)−0.032 (0.807)−0.178 (0.440)−0.030 (0.820)
 Small VLDL particle count−0.106 (0.409)−0.050 (0.695)−0.039 (0.764)0.136 (0.292)0.224 (0.086)0.062 (0.638)−0.015 (0.907)−0.121 (0.600)0.040 (0.764)
 Medium VLDL particle count−0.129 (0.314)−0.178 (0.164)0.254 (0.044)0.004 (0.978)0.010 (0.937)−0.057 (0.668)−0.026 (0.842)−0.197 (0.391)−0.073 (0.577)
 Large medium VLDL particle count−0.101 (0.433)−0.156 (0.223)0.241 (0.057)0.003 (0.983)0.010 (0.938)−0.055 (0.675)−0.037 (0.779)−0.179 (0.438)−0.089 (0.499)
 Large VLDL particle count0.094 (0.463)0.001 (0.998)0.017 (0.895)−0.007 (0.956)0.031 (0.812)0.023 (0.862)−0.054 (0.682)−0.103 (0.658)−0.116 (0.376)
Particle Size
 HDL particle size0.456 (<0.001)−0.257 (0.042)−0.106 (0.408)−0.211 (0.099)−0.006 (0.963)−0.101 (0.444)0.044 (0.741)0.135 (0.558)−0.103 (0.433)
 LDL particle size−0.200 (0.115)−0.027 (0.834)−0.186 (0.145)−0.249 (0.051)−0.152 (0.247)−0.068 (0.603)0.042 (0.752)−0.284 (0.212)0.273 (0.035)
 VLDL particle size−0.010 (0.941)−0.126 (0.325)−0.047 (0.712)−0.019 (0.882)−0.072 (0.585)−0.038 (0.774)−0.054 (0.683)−0.066 (0.776)−0.131 (0.320)
  • Univariate regressions reported as β-coefficient (p value).

  • Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p<0.00009 remain significant.

  • CCP, anti-cyclic citrullinated peptide; GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NMR, nuclear MR; VLDL, very low-density lipoprotein; anti-ENA, anti-extractable nuclear antigen; anti-RNP, anti-ribonuclear protein; anti-dsDNA, anti-double stranded DNA.