Table 2

A comparison of baseline laboratory and clinical data for patients with cSLE /APPLE between dichotomised GCN groups of total C4, C4A and C4B

Total C4 GCNC4A GCNC4B GCN
<4
(N=64)
≥4
(N=133)
P<2
(N=39)
≥2
(N=158)
P<2
(N=49)
≥2 (N=148)P
Age, years±SD15.0±0.315.9±0.20.0215.5±0.415.7±0.20.6915.0±0.415.8±0.20.063
Age of SLE diagnosis, years±SD12.5±3.113.5±2.80.03313.1±2.913.2±2.90.8512.8±3.113.3±2.80.25
Female, N (%)53 (82.8)110 (82.7)135 (89.7)128 (81.0)0.2437 (75.5)126 (85.1)0.13
Race, N (%)
 White17 (26.6)35 (26.1)0.817 (18.0)45 (28.3)0.3312 (24.5)40 (26.9)0.73
 African American32 (50.0)62 (46.3)22 (56.4)72 (45.3)22 (44.9)72 (48.3)
 Other/multi15 (23.4)37 (27.6)10 (25.6)42 (26.4)15 (30.6)37 (24.8)
BMI, kg/m2±SD23.1±0.724.9±0.50.0323.0±0.824.6±0.40.0923.6±0.824.5±0.40.28
Disease duration, mo ±SD29.8±3.529.2±2.50.8928.7±4.529.5±2.30.8827.4±4.030.1±2.30.56
SBP, mm Hg ±SD111.6±1.6113.8±1.10.25112.7±2.0113.2±1.00.83111.3±1.8113.7±1.00.23
DBP, mm Hg ±SD64.2±1.267.7±0.80.0165.5±1.666.8±0.80.4563.7±1.467.5±0.80.02
Hypertension, N (%)16 (25.0)38 (28.8)0.5814 (35.9)40 (25.5)0.207 (14.3)47 (32.0)0.02
Pericarditis N (%)3 (4.69)14 (10.5)0.152 (5.13)15 (9.49)0.361 (2.04)16 (10.8)0.03
Myositis N (%)9 (14.1)11 (8.27%)0.228 (20.5)12 (7.59)0.035 (10.2)15 (10.1)0.99
Serum C3, mg/dL102.5±3.6101.9±2.50.9106.3±4.6101.1±2.30.31100.6±4.0102.6±2.30.67
Serum C4, mg/dL11.7±0.916.8±0.71.2×10–513.3±1.315.6±0.60.1112.6±1.116.1±0.60.01
Lipoprotein (A)25.121.50.361923.60.3226.321.40.26
Homocysteine7.727.320.47.817.360.427.517.430.87
Total cholesterol152.1157.20.4159.4154.60.51154.4155.90.82
HDL46.346.90.7747.146.60.8345.547.10.44
LDL84.187.20.5388.285.70.6686.985.90.85
Triglycerides1091118.40.39120.3114.20.63110.5117.00.57
C-reactive protein2.282.780.692.282.700.782.002.820.55
CIMT, mm
 Mean–mean CIMT0.460.460.210.450.460.040.470.460.23
 Mean–mean common CIMT0.460.470.370.460.470.050.470.470.38
 Mean-max CIMT0.580.590.110.570.590.090.590.580.21
 Mean-max common CIMT0.590.600.370.580.60.030.610.600.12
  • APPLE, Atherosclerosis Prevention in Pediatric Lupus Erythematosus; BMI, body mass index; CIMT, carotid intima media thickness; DBP, diastolic blood pressure; GCN, gene copy number; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SBP, systolic blood pressure; SLE, systemic lupus erythematosus; cSLE, childhood-onset systemic lupus erythematosus.